二肽基肽酶抑制剂联合参芪降糖颗粒治疗2型糖尿病患者临床效果观察

Clinical Observation of Dipeptidyl Peptidase-4 Inhibitors Combined with Shenqi Jiangtang Granules in the Treatment of Type 2 Diabetes

目的:观察并初步研究二肽基肽酶抑制剂联合参芪降糖颗粒治疗2型糖尿病的临床效果。方法:将106例入院的2型糖尿病患者随机分为两组,各53例。对照组采用参芪降糖颗粒治疗,治疗组采用西格列汀和参芪降糖颗粒治疗,对比分析两组患者的临床疗效。结果:术后治疗组总有效率为92.45%,显著高于对照组75.47%(P<0.05);与治疗前相比,治疗后两组患者的空腹血糖、餐后2 h血糖和糖化血红蛋白均有所改善,差异显著(P<0.05);治疗组各指标改善程度均优于对照组,差异有统计学意义(P<0.05);治疗期间,治疗组低血糖发生率(1.9%)低于对照组(9.4%),差异有统计学意义(P<0.05)。结论:二肽基肽酶抑制剂联合参芪降糖颗粒治疗2型糖尿病可明显改善患者的治疗效果,减少患者并发症的发生,在临床实践中值得广泛参考。

Objective:To investigate the clinical effects of dipeptidyl peptidase-4 inhibitors combined with Shenqi Jiangtang granules in treating type 2 diabetes.Methods:A total of 106 hospitalized patients with type 2 diabetes were randomly divided into two groups,53 for each.The control group with shenqi jiangtang granules only,and the treatment group was treated with dipeptidyl peptidase-4 inhibitors combined with Shenqi Jiangtang granules.The clinical efficacy of the two groups was compared and analyzed.Results:The total effective rate of the postoperative treatment group was 92.45%,significantly higher than that of the control group(P<0.05);Compared with before treatment,fasting blood glucose,postprandial blood glucose and glycosylated hemoglobin were improved in the two groups after treatment,with significant difference(P<0.05).The improvement degree of all indicators in the treatment group was better than that in the control group,with statistically significant difference(P<0.05).During the treatment period,the incidence of hypoglycemia in the treatment group(1.9%)was lower than that in the control group(9.4%),and the difference was statistically significant(P<0.05).Conclusion:Dipeptidyl peptidase-4 inhibitors combined with Shenqi Jiangtang granules had significant effect in treating type 2 diabetes,which can obviously improve the treatment effect of patients,reduce the occurrence of patient complications,it is worthy of extensive reference in clinical practice.