厄贝沙坦与氨氯地平治疗2型糖尿病合并高血压的临床探讨

Clinical Study of Irbesartan and Amlodipine in the Treatment of Type 2 Diabetes Complicatedwith Hypertension

目的:分析厄贝沙坦与氨氯地平治疗2型糖尿病合并高血压的临床疗效。方法:选取某院2016年9月~2018年11月于门诊就诊的2型糖尿病合并高血压患者66例,进行计算机抽样分组。对照组患者31例给予单纯氨氯地平进行治疗,研究组患者35例在对照组基础上加以厄贝沙坦联合治疗,对两组患者治疗前后血糖水平、舒张压和收缩压、治疗疗效以及不良反应等进行分析观察。结果:研究组患者治疗前空腹血糖、餐后2h血糖水平和对照组差异不大(P>0.05),治疗后差异显著(P<0.05);研究组患者治疗前血压水平(收缩压、舒张压)与对照组差异不明显(P>0.05),治疗后差异显著(P<0.05);治疗疗效上研究组为94.29%(33/35),对照组为77.42%(24/31),组间差异较大(P<0.05);研究组不良反应胃肠道反应1例、头晕1例,对照组胃肠道反应1例、头晕1例,恶心1例,组间差异并无统计学意义(P>0.05)。结论:针对2型糖尿病患者合并高血压给予氨氯地平联合厄贝沙坦治疗后取得良好成效,可有效提高治疗疗效,在控制血压的同时还能改善血糖水平,同时还具有较高安全性,临床上值得推广应用。

Objective:To analyze the clinical effect of irbesartan and amlodipine in the treatment of type 2 diabetes mellitus complicated with hypertension.Methods:A total of 66 patients with type 2 diabetes complicated with hypertension treated in an outpatient clinic from September 2016 to November 2018 were selected for computer sampling and grouping.31 patients in the control group were treated with amlodipine alone,in the study group,35 patients were given irbesartan combined treatment on the basis of the control group.The blood glucose level,diastolic and systolic blood pressure,therapeutic effect and adverse reactions of the two groups of patients before and after treatment were analyzed and observed.Results:The fasting blood glucose and the 2h postprandial blood glucose level in the study group were not significantly different from those in the control group(P>0.05).There was no significant difference between the blood pressure level(systolic blood pressure and diastolic blood pressure)of the study group before treatment and the control group(P>.05),but there was significant difference after treatment(P<0.05).In terms of therapeutic effect,the study group was 94.29%(33/35),the control group was 77.42%(24/31),and the difference between groups was large(P<0.05);There were 1 case of adverse gastrointestinal reactions and 1 case of dizziness in the study group,1 case of gastrointestinal reactions,1 case of dizziness and 1 case of nausea in the control group,and the difference between the groups was not statistically significant(P>0.05).Conclusion:Patients with type 2 diabetes with hypertension and amlodipine combined with irbesartan have achieved good results,which can effectively improve the therapeutic effect,improve blood sugar while controlling blood pressure,and also have high safety.It is worth popularizing and applying clinically.