tau蛋白与阿尔茨海默病

tau protein and Alzheimer’s disease

背景:神经元纤维缠结的沉积与阿尔茨海默病中的认知衰退密切相关,而tau蛋白是构成的重要成分。目的:探讨阿尔茨海默病的可能发病机制以及tau蛋白过度磷酸化在阿尔茨海默病进程中的作用。方法:由第一作者以“阿尔茨海默病;tau蛋白;β-淀粉蛋白级联;Alzheimer’s disease;tau protein;β-amyloid cascade”为检索词,检索万方、中国知网、Vip、PubMed、Embase等中英文数据库2001年1月至2019年1月发表的相关文献。结果与结论:tau蛋白过度磷酸化并形成成对螺旋丝被认为是阿尔茨海默病神经元退化基础。tau蛋白在阿尔茨海默病的发病进程中可能不依赖于β-淀粉样蛋白沉积触发的级联反应,且在临床试验中也验证了tau蛋白相关疫苗免疫产生了疗效。探索tau蛋白和β-淀粉样蛋白以及阿尔茨海默病关系,可更好理解阿尔茨海默病的发病机制,为研发阿尔茨海默病治疗药物提供理论依据。

BACKGROUND:Deposition of neurofibrillary tangles is closely related to cognitive decline in Alzheimer’s disease,and tau protein is an important component.OBJECTIVE:To investigate the possible pathogenesis of Alzheimer’s disease and the role of tau protein hyperphosphorylation in the progression of Alzheimer’s disease.METHODS:The first author searched for relevant articles published from January 2001 to January 2019 in WanFang,CNKI,Vip,PubMed,and Embase with the key words of“Alzheimer’s disease;tau protein;β-amyloid cascade.”RESULTS AND CONCLUSION:Hyperphosphorylation of tau protein and formation of paired helix filaments are considered to be the basis of neuronal degradation in Alzheimer’s disease.tau protein may not depend on the cascade response triggered byβ-amyloid deposition in the pathogenesis of Alzheimer’s disease,and tau protein-associated vaccine immunity has been verified to produce a curative effect in clinical trials.Further exploration on the relationship between tau protein,β-amyloid protein and Alzheimer’s disease is necessary to better understand the pathogenesis of Alzheimer’s disease,and provide a theoretical basis for the development of therapeutic drugs for Alzheimer’s disease.