Schiff碱及其金属配合物与牛血清白蛋白相互作用的研究进展

Progress on the Interaction of Schiff Base and its Metal Complexes with Bovine Serum Albumin

席夫(Schiff)碱及其金属配合物具有抑菌、抗癌、抗病毒等各种生物活性。与血清白蛋白亲和力的大小关系着体内生物活性物质的转移和分配,研究牛血清白蛋白(BSA)与Schiff碱化合物的相互作用,为药物小分子与生物大分子结合提供实验数据和理论参考。根据构效关系,设计合成生物活性高的Schiff碱化合物,并将其作为检测生物大分子的荧光探针,引起国内外研究者的广泛兴趣。综述了近年来Schiff碱及其金属配合物与BSA相互作用的研究,提出了未来发展思路。

Schiff base and its metal complexes have antibacterial,bactericidal,anti-tumor,anti-virus and other biological activities.The transfer and distribution of bioactive substances in vivo are related to the affinity of serum albumin.It can provide experimental reference and theoretical basis for the combination of small molecular drugs and albumin that exploring the interaction mechanism between Schiff base and its metal complexes and bovine serum albumin.The design and synthesis of schiff base compounds,using its own or metal complexes as the fluorescent probe of biomacromolecules,has been widely valued by researchers at home and abroad.In this paper,the study of the interaction of Schiff base and its complex with bovine serum albumin in recent years has been reviewed,its development direction is also prospected.