摘要
随着人们生活方式和饮食结构的改变,非酒精性脂肪性肝病(NAFLD)发病率逐年上升,严重威胁人类健康。NAFLD疗法一直是基础和临床肝病研究的热门领域。近年来,诸多研究揭示omega-3多不饱和脂肪酸(ω3-PUFA)可促进脂肪酸氧化并改善肠道稳态,从而改善脂代谢和肝脏炎症,因而越来越多的临床研究开始将ω3-PUFA运用于NAFLD的治疗中。然而,ω3-PUFA治疗NAFLD的机制尚不明确,相关临床研究也存在一定局限性。主要介绍了ω3-PUFA在NAFLD中发挥的作用以及相关的临床研究结果,并进一步讨论ω3-PUFA治疗NAFLD尚需解决的问题。
With the changes in people’s lifestyle and dietary structure,the incidence rate of nonalcoholic fatty liver disease(NAFLD) has been increasing year by year,and NAFLD has become a serious threat to human health. The treatment of NAFLD has always been a hot topic of basic and clinical research on liver diseases. In recent years,many studies have revealed that omega-3 polyunsaturated fatty acids(ω3-PUFA) can promote fatty acid oxidation,improve intestinal homeostasis,and thus improve lipid metabolism and liver inflammation,and therefore,more and more clinical studies have applied ω3-PUFA in the treatment of NAFLD. However,the mechanism of ω3-PUFA in the treatment of NAFLD is still unclear,and there are certain limitations in related clinical studies. This article mainly introduces the role of ω3-PUFA in NAFLD and the results of related clinical studies and further discusses the problems that need to be solved in ω3-PUFA for the treatment of NAFLD.
作者
郭悦承
陆伦根
GUO Yuecheng;LU Lungen(Department of Gastroenterology,Shanghai General Hospital,Shanghai 200080,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2020年第1期198-200,共3页
Journal of Clinical Hepatology
关键词
非酒精性脂肪性肝病
脂肪酸类
ω3
治疗学
non-alcoholic fatty liver disease
fatty acids,omega-3
therapeutics