中性粒细胞胞外诱捕网的形成机制及在肝病中的作用

Formation mechanism of neutrophil extracellular traps and their role in liver diseases

中性粒细胞胞外诱捕网(NETs)是近年来新发现的中性粒细胞杀灭病原体的一种新的免疫机制。NETs的主要成分是DNA,上面附着大小不一的颗粒蛋白。NETs在肝缺血再灌注损伤、慢性乙型肝炎、肝硬化和肝癌等肝病中扮演着不同的角色。阐述了NETs的形成机制、结构组成和其在肝病中作用的研究进展。

Neutrophil extracellular traps(NETs) have recently been found to be a new immune mechanism for neutrophils to kill pathogens.The main component of NETs is DNA,with granular proteins of different sizes attached to the surface. NETs play different roles in various liver diseases such as hepatic ischemia-reperfusion injury,chronic hepatitis B,liver cirrhosis,and liver cancer. This article reviews the formation mechanism,structure,and role of NETs in liver diseases.