门静脉性肺动脉高压的研究现状

Current status of the research on portopulmonary hypertension

门静脉性肺动脉高压(POPH)是在门静脉高压基础上发生的肺动脉压力升高,随着病情的进展导致进行性右心功能衰竭并最终死亡。该病发病率低,由于患者早期无症状或非特异性症状,常被临床医生忽视。总结近年来该病的发病机制、诊断及治疗的进展,介绍目前POPH诊断可应用的无创检测方法,探讨根据POPH的严重程度及个体化情况选择恰当的治疗方式,提高临床医生对该病的认识。

Portopulmonary hypertension(POPH) refers to the increase in pulmonary artery pressure on the basis of portal hypertension,which may lead to progressive right ventricular failure and death with disease progression. POPH has a low incidence rate and is often neglected by clinicians due to a lack of symptoms or the presence of non-specific symptoms in the early stage. This article summarizes the research advances in the pathogenesis,diagnosis,and treatment of POPH in recent years,introduces the noninvasive detection methods currently available for POPH diagnosis,and explores the selection of appropriate treatment methods based on the severity and individualized conditions of patients with POPH,so as to improve the understanding of this disease among clinicians.