X染色体编码的miRNA在自身免疫病发生发展中作用的研究进展

Association of X-Chromosome encoded miRNAs with pathogenesis of autoimmune diseases

自身免疫性疾病是一组病因未明的慢性炎症性疾病。其特征在于自身反应性T、B淋巴细胞过度活化,自身抗体大量产生以及多器官多系统广泛损害,且女性发病率明显高于男性。miRNA是一类内源性非编码RNA分子。X染色体可编码116种miRNA,其中约16%的X染色体编码miRNA与免疫有关。近年来研究发现在多种自身免疫病中存在miRNA的异常表达,表明miRNA与多种自身免疫病的发生发展密切相关。本文将主要对X染色体编码的miRNA在自身免疫病发病机制中的研究进展进行综述。

Autoimmune disease is a group of chronic inflammatory disease whose etiology is unknown.It is characterized by over-activation of autoreactive T and B lymphocytes,large production of autoantibodies,extensive damage to multiple organs and system.The incidence is significantly higher in females than in males.miRNAs are class of endogenous non-coding RNA molecules.X chromosome encodes 116 miRNAs,16% of which are involved in immunity.In recent years,studies have found that miRNAs are abnormally expressed in various autoimmune diseases,indicating that miRNAs are closely related to the occurrence and development of these diseases.This study focused on X chromosome encoded miRNAs and their involvement in the pathogenesis of autoimmune diseases.