胸腺上皮细胞自噬在T细胞分化发育中的研究进展

Advances of autophagy in thymic epithelial cells for differentiation and development of T cells

胸腺作为中枢免疫器官,通过影响T细胞的分化输出,调节外周T细胞稳态,与多种免疫性疾病密切相关。研究表明,胸腺上皮细胞与胸腺内T细胞分化发育密切相关。而自噬作为机体内维持自身稳态重要过程,在胸腺内T细胞的阳性选择和阴性选择过程必不可少。因此,本文就胸腺上皮细胞自噬在T细胞分化发育中的作用作一综述。

As a central immune organ,thymus regulates the differentiation of T cells and regulates the homeostasis of peripheral T cells,which is closely related to various immune diseases.Studies have shown that thymic epithelial cells are closely related to the differentiation and development of T cells in the thymus.Autophagy,as an important process to maintain homeostasis in the body,plays critical roles in the positive and negative selection of T cells in the thymus.Therefore,this article reviews the role of thymic epithelial cells autophagy in the differentiation and development of T cells.