学龄前儿童高热惊厥胼胝体弥散张量成像研究

Study on diffusion tensor imaging of corpus callosum in preschool children with febrile convulsion

目的利用弥散张量成像(DTI)对学龄前高热惊厥儿童患者胼胝体各部进行检测分析,观察胼胝体各部微观变化,分析DTI对高热惊厥患儿上述变化的相关性。方法选择2013年6月至2019年1月在我院行DTI检查病例180例,因高热惊厥抽搐患儿90例设为观察组,因头痛等非高热及无神经系统感染阳性体征患儿90例设为对照组。两组均进行颅脑磁共振弥散张量成像(DTI)检查。分别于胼胝体各部设置感兴趣区,测量出各向异性分数(FA)值及表面扩散系数(ADC)值,并结合临床特点进行相关性分析。结果观察组胼胝体各部FA均较对照组明显减低,ADC值均较对照组明显增加,观察组胼胝体前1/3部及前体部、压部FA值低于对照组,观察组胼胝体前1/3部及压部ADC值高于对照组,差异有统计学意义(P<0.05)。结论DTI对学龄前高热惊厥患儿的诊断比常规MRI更敏感,可作为高热惊厥检测及病情评估的敏感指标。

Objective To detect and analyze the parts of corpus callosum in preschool children with febrile convulsion by diffusion tensor imaging(DTI),to observe the microscopic changes of corpus callosum,and to analyze the relationship between DTI and those changes.Methods A total of 180 children received DTI examination in our hospital from June 2013 to January 2019:90 children with febrile convulsion were included in observation group and 90 with headache and without positive signs of nervous infection were in the control group.The children in both groups underwent DTI examination.The interested area was set respectively at every part of corpus callosum,and the FA and ADC values were determined,which were combined with clinical characteristics to make correlation analysis.Results The FA value of all parts of corpus callosum was significantly decreased in observation group compared with that in control group,while ADC value was significantly increased;the FA value in the anterior 1/3 and the anterior part and the compression part in observation group was lower than that in control group;the ADC value in the anterior 1/3 and the compression part in observation group was higher than that in control group;the difference was statistically significant(P<0.05).Conclusion DTI is more sensitive than conventional MRI in the diagnosis of preschool children with febrile convulsion and it can serve as a sensitive index in the detection and disease evaluation of febrile convulsion.