基于无机纳米材料调节自噬治疗肿瘤的研究进展

Advances in inorganic nanomaterials regulated autophagy in cancer treatment

自噬作为维持细胞稳态的基本机制之一,在肿瘤发生发展的过程中发挥多种重要的生物学作用。无机纳米材料因其自身具有特异的物化性质,辅以易修饰、靶向性等特点,其可被应用于调节自噬用于控制肿瘤的发生发展并最终实现治疗。文章主要就近年来金纳米粒子、银纳米粒子、氧化铁纳米粒子、富勒烯C60纳米材料、氧化石墨烯纳米材料这几种代表性的无机纳米材料应用于调控肿瘤细胞自噬并实现相关治疗的研究进展进行综述。

Autophagy represents one of the essential cellular mechanism to maintain homeostasis within cells,performing multiple biological functions during tumorigenesis.Base on the unique physicochemical properties of inorganic nanomaterials,supplemented by easy modification and targeting and so on,they could be used to regulate autophagy,controlling the occurrence and development of tumor and finally achieve treatment.This article primarily reviews the application of several representative inorganic nanomaterials,such as Gold nanoparticles,Silver nanoparticles,Iron oxide nanoparticles,Fullerene C60 nanomaterials,Graphene oxide nanomaterials in regulating autophagy of tumor cells and achieving treatment in recent years.