骨髓来源的抑制性细胞在感染性疾病中的研究进展

Advances in research on infection of Myeloid-derived suppressor cells

骨髓来源的抑制性细胞(MDSCs)是新近发现来源于骨髓并对机体免疫起抑制作用的细胞。其在肿瘤、感染以及自身免疫性疾病中起免疫抑制作用,在疾病模型研究中证实其免疫抑制作用主要是通过抑制T细胞的功能来实现。目前,感染性疾病的治疗仍是一大难题,特别是在慢性感染性疾病的治疗,研究发现MDSCs在感染性疾病中出现聚集增多的现象,因此MDSCs在感染性疾病方面的研究得到了更多学者的重视,其潜在治疗作用可能将被进一步的挖掘。文章主要从MDSCs在细菌、病毒、寄生虫以及真菌等感染性疾病方面的免疫抑制机制及其与疾病的关系等方面进行综述。

Myeloid-derived suppressor cells(MDSCs)are newly discovered cells derived from bone marrow that suppress immunity,playing an immunosuppressive role in tumors,infections,and autoimmune diseases.It has been confirmed in disease model studies that their immunosuppressive effect is mainly achieved by suppressing the function of T cells.At present,the treatment of infectious diseases is still a major obstacle,especially in the treatment of chronic infectious diseases.Studies have found that MDSCs have increased aggregation in infectious diseases.As MDSCs are gaining more attention in infectious diseases,their potential therapeutic effects may be further explored.This article mainly reviews the immunosuppressive mechanisms of MDSCs in infections such as bacteria,viruses,parasites and fungi and their relationship with the diseases.