伯基特淋巴瘤化疗后合并巨细胞病毒视网膜炎一例

A case of cytomegalovirus retinitis after chemotherapy of Burkitt’s lymphoma

目的提高对伯基特淋巴瘤化疗后合并巨细胞病毒视网膜炎的认知。方法分析1例58岁伯基特淋巴瘤化疗后合并巨细胞病毒视网膜炎患者的诊治过程,并结合相关文献进行复习。结果该例伯基特淋巴瘤患者多疗程化疗后病情缓解,缓解后出现长期营养不良,抵抗力低下,免疫重建受损,诱发巨细胞病毒感染并引起巨细胞病毒视网膜炎,经更昔洛韦注射液抗病毒治疗后巨细胞病毒DNA低于检测下限,视力逐渐改善。结论及时确诊及规范治疗是控制免疫化疗后合并巨细胞病毒视网膜炎病情及改善预后的关键。

Objective To improve the awareness of cytomegalovirus retinitis after chemotherapy of Burkitt’s lymphoma.Methods The diagnosis and treatment of one 58-year-old patient of cytomegalovirus retinitis after chemotherapy of Burkitt’s lymphoma was analyzed and relevant literatures were reviewed.Results The condition of this patient with Burkitt’s lymphoma was relieved after multicourse chemotherapy,but immune system reconstruction failed due to long-term malnutrition and low resistibility,which led to cytomegalovirus infection and cytomegalovirus retinitis.After antiviral treatment with ganciclovir injection,cytomegalovirus DNA was negative and the vision gradually improved.Conclusions Timely diagnosis and standard treatment are the keys to control cytomegalovirus retinitis after immunochemotherapy of Burkitt’s lymphoma.