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阿瑞匹坦用于卵巢恶性肿瘤含铂方案化疗止吐效果的临床观察 被引量:1

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摘要 目的观察阿瑞匹坦用于卵巢恶性肿瘤含铂方案化疗的止吐效果。方法回顾性分析我院妇科2018年10月至2019年6月收治的卵巢恶性肿瘤73例,分为研究组38例与对照组35例,均给以铂类为主的联合化疗,研究组予阿瑞匹坦预防呕吐,对照组予昂丹司琼片预防呕吐,比较两组的止吐有效率,观察两组呃逆、腹胀、便秘、腹泻等主要副作用的发生率。结果研究组预防急性呕吐的有效率为78.95%,对照组的有效率为74.29%,两组对比P值>0.05差异无统计学意义,研究组预防迟发性呕吐的有效率为81.58%,对照组的有效率为57.14%,两组对比P值<0.05差异有统计学意义。研究组和对照组呃逆、腹胀、腹泻的发生率分别为11.43%和5.71%、13.16%和20.20%、5.26%和5.71%,两两对比P值>0.05差异无统计学意义。研究组和对照组便秘发生率分别为11.43%和31.43%,P值<0.05,差异有统计学意义,对照组便秘发生率高于研究组。结论阿瑞匹坦止吐效果好,副作用小,值得在卵巢恶性肿瘤的化疗止吐中推广使用。
作者 江瑜 宋保志
出处 《海峡药学》 2019年第12期131-132,共2页 Strait Pharmaceutical Journal
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