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曲普瑞林联合米非司酮治疗子宫肌瘤的临床疗效及安全性分析 被引量:4

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摘要 目的探讨对子宫肌瘤患者实施曲普瑞林联合米非司酮进行治疗的临床疗效和安全性。方法选取2017年5月~2019年5月收治的子宫肌瘤病例102例,对照组实施米非司酮单独用药,观察组实施曲普瑞林联合米非司酮用药,对比各患者用药前后临床数项指标变化,同时对比各患者临床疗效和不良反应情况。结果用药前患者各项指标均无显著差异(P>0.05);用药后患者各项指标均明显好转,其中观察组较对照组改善显著(P<0.05);此外,观察组的总有效率较对照组明显提升(P<0.05),而观察组与对照组的不良反应情况未见明显差异(P>0.05)。结论对子宫肌瘤患者实施曲普瑞林联合米非司酮治疗可以有效缓解患者表征,具有优越的临床疗效和较高的安全性,实际应用切实可行。
出处 《海峡药学》 2019年第12期153-155,共3页 Strait Pharmaceutical Journal
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  • 1Markowski DN,Bartnitzke S,Loning T. MED12 mutations in uterine Ubreids-their relationship to eytogenetic subgroups[ J]. International Journal of Cancer,2012,131 (7) :1528 -1536.
  • 2Mskinen N, Vahteristo P, BOtzow R, et al. Exomic landscape of MED12 mutation-negative and-positive uterine leiomyomas[ J]. In- ternational Journal of Cancer,2014,134(4) :1008 - 1012.
  • 3Matsubara A ,Sekine S ,Yoshida M. Prevalence of MED12 mutations in uterine and extrauterine smooth muscle tumours[ J]. Histopathol- ogy,2013,62(4) :657 -661.
  • 4Schwetye KE,Pfeifer JD,Duneavage EJ. MED12 exon 2 mutations in uterine and extrauterine[ J]. Human Pathology,2014,45(1):65 - 70.
  • 5Shaik NA,Lone WG,Khan IA. Detection of somatic mutations and germline polymorphismsin mitoehondrial DNA of uterine fihroids pa- tients[ J]. Genetic Testing and Molecular Biomarkers,2011,15 (7/ 8) :537 -541.
  • 6Sabry M,A1-Hendy A. Medical treatment of uterine leiomyoma[J]. Reproductive Sciences ,2012,19 (4) :339 - 353.
  • 7Parker WH. Etiology, symptomatology, and diagnosis of uterine myo- mas[J]. Fertility and Sterility,2007,87(4) :725 -736.
  • 8Sefton EC, Kim JJ. The role of progesterone signaling in the patho- genesis of uterine leiornyoma [ J ]. Molecular and Cellular Endocri- nology,2012,358(2) :223 -231.
  • 9Yoshida S, Ohara N, Xu Q. Cell-type specific actions of progesterone receptor modulators in the regulation of uterine leiomyoma growth[J]. Seminars in Reproductive Medicine,2010,28(3):260- 273.
  • 10Qin J, Yang T, Kong F, et al. Oral contraceptive use and uterine leiomyoma risk: a recta-analysis based on cohort and ease-control studies[J]. Archives of Gynecology and Obstetrics,2013,288(1) : 139 - 148.

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