摘要
普鲁兰糖是由出芽短梗霉产生的一种胞外多糖,在食品、药物、化妆品等领域有广泛应用,但其具体的分子合成机制和分子量调控机制尚不明确。本文回顾了近年普鲁兰糖生物合成途径及分子量调控机制研究,并绘制了可能的普鲁兰糖合成途径,总结了影响普鲁兰糖产量和分子量的因素。
Pullulan is an extracellular polysaccharide produced by Aureobasidium pullulans,which is widely used in food,medicine,cosmetics and other fields.However,the specific biosynthetic pathway and molecular weight regulation mechanism of pullulan are still unclear.Recent research on those topics are reviewed,and a proposal biosynthetic pathway of pullulan is concluded.And the factors that influence yield and molecular weight of pullulan are also summarized in this paper.
作者
刘飞
刁梦奇
张金华
张林军
袁超
王凤山
凌沛学
LIU Fei;DIAO Meng-qi;ZHANG Jin-hua;ZHANG Lin-jun;YUAN Chao;WANG Feng-shan;LING Peixue(3(1.School of Pharmaceutical Sciences,Shandong University,Jinan 250012,China;Key Laboratory of Biopharmaceuticals,Engineering Laboratory of Polysaccharide Drugs,National-Local Joint Engineering Laboratory of Polysaccharide Drugs,Postdoctoral Scientific Research Workstation,Shandong Academy of Pharmaceutical Sciences,Jinan 250101,China;Shandong Freda Pharmaceutical Group Co.,Ltd.,Jinan 250101,China)
出处
《食品与药品》
CAS
2020年第1期72-77,共6页
Food and Drug
基金
山东省级重点实验室专项建设计划(SDKL2017023)
山东省自然科学基金(ZR2017BH051)
山东省重点研发计划(2018GSF121033,2018GHY115009,2018GSF118099,2019GSF107040,2019GSF108225,2019GHY112009)
泰山学者工程专项
山东省管企业人才发展支持项目
山东省属企业重大技术创新及产业化项目“多糖类药物研究开发关键技术”。
关键词
普鲁兰糖
出芽短梗霉
生物合成途径
分子量调控
pullulan
Aureobasidium pullulans
biosynthetic pathway
molecular weight regulation
