血清ApoB/ApoA-I比值与男性不育症患者精子质量相关性分析

Correlation of serum ApoB/ApoA-I ratio with the sperm quality in male infertile patients

目的分析男性不育症患者血清载脂蛋白B与载脂蛋白A-I比值(ApoB/ApoA-I)和精子质量的相关性。方法对46例受试者(24例男性不育患者,22名正常生育力男性)进行精子质量评估,包括精液量、pH以及精子浓度、精子总活力、前向运动精子率和正常形态精子率;全自动生化仪检测受试者血清ApoB和ApoA-I水平;比较健康组与不育组精子质量和ApoB/ApoA-I水平;Spearman法分析不育组内ApoB/ApoA-I与精子质量的相关性。结果不育男性精子浓度、总活力、正常形态精子率和前向运动精子率均低于健康男性(P<0.001),但ApoB/ApoA-I比值高于健康男性(P<0.05);ApoB/ApoA-I与精子浓度、精子总活力、前向运动精子率和正常形态精子率呈显著负相关关系。结论 ApoB/ApoA-I比值升高与男性不育患者的精子质量受损存在明显的相关性。

Objective To analyze the correlation between the ratio of serum Apolipoprotein B to Apolipoprotein A-I(ApoB/ApoA-I) and the sperm quality in infertile male patients. Methods The sperm quality of 46 subjects(infertile males, n=24;healthy males, n=22) were assessed including the volume, pH, concentration, activate rate, progressive motility and normal morphology percentage of sperm. Serum ApoB and ApoA-I levels were detected by automatic biochemistry analyzer. Sperm quality and ApoB/ApoA-I ratio were compared between healthy and infertile males. Correlation between ApoB/ApoA-I and sperm quality in infertile males was analyzed using Spearman analysis. Results The concentration, activate rate, progressive motility and normal morphology percentage of sperm in infertile males were significantly lower than those in healthy males(P<0.001), while the ApoB/ApoA-I ratio was higher(P<0.05). Spearman analysis showed that the ApoB/ApoA-I ratio was negatively correlated with sperm density, sperm activate rate, progressive sperm motility and normal sperm morphology percentage in infertile males. Conclusions Higher ApoB/ApoA-I ratio is significantly correlated with the poor sperm quality in infertile males.