摘要
目的:采用Meta分析的方法,评价咀嚼无糖口香糖对血液透析患者口腔干燥症干预的效果。方法:检索中国知网、万方、维普、中国生物医学、Pubmed、Embase、Cochance、Web of science、Ovid及CINAHL数据库中有关咀嚼无糖口香糖对血液透析患者口腔干燥症干预效果的随机对照试验或半随机临床试验。将符合纳入、排除标准的研究进行数据提取和质量评价后,使用Review Manager 5.3软件对结局指标进行Meta分析。结果:共纳入5项研究,包括237名患者。结果显示,咀嚼无糖口香糖能改善患者的口干症状[MD=-2.12,95%CI(-2.53,-1.71),P<0.001];但对患者透析间的口渴症状[MD=-1.57,95%CI(-3.41,0.27),P=0.09]和体重增加[MD=-0.38,95%CI(-1.02,0.27),P=0.25]没有影响。结论:咀嚼无糖口香糖对血液透析患者的口干症状有所改善,但对患者透析间口渴症状和体重增加无影响。但由于本研究纳入的文献数量较少,且文献质量不高,因此仍需开展大样本、多中心的高质量随机对照试验,以进一步探讨咀嚼无糖口香糖对血液透析患者口腔干燥症的干预效果。
Objective:Meta-analysis was used to evaluate the effect of chewing sugar-free gum on xerostomia in hemodialysis patients.Methods:Randomized controlled trials or semi-randomized clinical trials on the effects of chewing sugarless gum on xerostomia in hemodialysis patients were retrieved from the databases of Chinese national knowledge infrastructure(CNKI),Wanfang,Chinese sci-tech periodical full text databases Whipple(VIP),Chinese biomedical(CBM),Pubmed,Embase,Cochance,Web of science,Ovid and CINAHL.After data extraction and quality evaluation,we used Review Manager 5.3 software to carry out meta-analysis of the outcome indicators.Results:Five studies enrolled 237 patients were included eventually.The results showed that chewing sugar-free gum improved the symptoms of dry mouth[MD=-2.12,95%CI(-2.53,-1.71),P<0.001],but had no effect on patients'thirst symptoms[MD=-1.57,95%CI(-3.41,0.27),P=0.09]and weight gain[MD=-0.38,95%CI(-1.02,0.27),P=0.25]during dialysis.Conclusion:Chewing sugar-free gum can improve the dry mouth of hemodialysis patients,but it has no effect on thirst and weight gain during dialysis.However,due to the small number and the low quality of included literatures,it is still necessary to carry out large sample,multi-center and high-quality randomized controlled trials to further explore the effect of chewing sugar-free gum on xerostomia in hemodialysis patients.
