注射用盐酸万古霉素与注射用头孢哌酮钠/舒巴坦钠配伍禁忌及相关文献分析

Incompatibility of Vancomycin Hydrochloride for Injection and Cefoperazone/Sulbactam for Injection and Related Literature Analysis

目的:检索万古霉素和头孢哌酮钠/舒巴坦钠相关配伍禁忌文献,预防临床输注药物时配伍禁忌的发生。方法:通过1例万古霉素和头孢哌酮钠/舒巴坦钠序次输注产生白色沉淀的案例,检索两种药物相关配伍禁忌文献并进行分析,为临床合理使用万古霉素和头孢哌酮钠/舒巴坦钠提供参考。结果:万古霉素与12种药物有配伍禁忌,均出现白色浑浊或沉淀,其中只有1种药物(头孢地嗪)说明书有提示。头孢哌酮钠/舒巴坦钠与21种药物有配伍禁忌,2种出现变色(红色),19种出现白色浑浊或沉淀,其中只有3种药物(依替米星、庆大霉素、亚胺培南/西司他丁钠)说明书提示配伍禁忌。结论:万古霉素与头孢哌酮钠/舒巴坦钠有配伍禁忌,必须分开输注;对于文献中提到的药物在与万古霉素或头孢哌酮钠/舒巴坦钠同时使用时需要科学安排输注顺序或者采用间隔冲管的方式。

Objective:To retrieve the related literature of incompatibility of vancomycin hydrochloride for injection and cefoperazone/sulbactam for injection,so as to prevent the occurrence of incompatibility in clinical infusion.Methods:A case of white precipitation caused by sequential infusion of vancomycin and cefoperazone/sulbactam was observed,the related literature of incompatibility of two drugs were retrieved and analyzed to provide reference for the clinical rational use of vancomycin and cefoperazone/sulbactam.Results:Vancomycin had incompatibility with 12 kinds of drugs,all of which were white turbidity or precipitation,and only one drug(ceftizine)was labeled in the instructions.Cefoperazone/sulbactam had incompatibility with 21 kinds of drugs,2 kinds of drugs showed discoloration(red),and 19 kinds of drugs showed white turbidity or precipitation,of which only 3 kinds of drugs(etimicin,gentamicin,imipenem/sitastatin)indicated incompatibility in the instructions.Conclusion:There is incompatibility between vancomycin hydrochloride and cefoperazone/sulbactam,which must be administered separately.For the drugs mentioned in the literature,when they are used simultaneously with vancomycin or cefoperazone/sulbactam,it is necessary to scientifically arrange the infusion sequence or use the interval flushing method.