超声弹性成像联合超声造影在早期乳腺癌诊断中的价值研究

Diagnostic value of ultrasound elastography combined with contrast-enhanced ultrasound in breast cancer

目的探究超声弹性成像联合超声造影在早期乳腺癌中的诊断价值。方法对乳腺病灶切除术患者113例(140个乳腺肿块)分别进行超声弹性成像技术、超声造影、超声弹性成像联合超声造影检查,以病理结果为对照,比较诊断灵敏度、特异度、准确度。结果140个病灶中,恶性90例(病灶98个),良性23例(病灶42个)。超声弹性成像与超声造影诊断早期乳腺癌灵敏度、特异度、准确度分别为73.47%、80.95%、75.71%与77.55%、85.71%、80.00%,差异均无统计学意义(χ^2分别=0.44、0.34、0.74,P均>0.05);超声弹性成像联合超声造影诊断的灵敏度、特异度、准确度分别为91.84%、90.47%、91.43%,灵敏度和准确度均明显高于单纯采用超声弹性成像或超声造影,差异均有统计学意义(χ^2分别=7.71、11.52、7.46、12.59,P均<0.05)。结论超声弹性成像联合超声造影在早期乳腺癌中具有良好诊断效果与鉴别诊断价值。

Objective To explore the diagnostic value of ultrasound elastography combined with contrast-enhanced ultrasound in breast cancer.Methods Totally 113 patients(140 breast tumors)who underwent breast focus resection were examined by ultrasound elastography,contrast-enhanced ultrasound,and contrast-enhanced ultrasound combined with contrast-enhanced ultrasound.Compared with pathological results,the sensitivity,specificity and accuracy among three methods were calculated and compared.Results Of the 140 lesions,90 cases were malignant(98 lesions)and 23 cases were benign(42 lesions).The sensitivity,specificity and accuracy of ultrasound elastography and CEUS in the diagnosis of early breast cancer were 73.47%,80.95%,75.71%and 77.55%,85.71%,80.00%,respectively,with no statistical difference(χ^2=0.44,0.34,0.74,P>0.05).The diagnostic sensitivity and accuracy of ultrasound elastography combined with CEUS were significantly higher than that either of ultrasound elastography or CEUS,which were 91.84%and 91.43%,respectively,with statistically significant differences(χ^2=7.71,11.52,7.46,12.59,P<0.05).Conclusion Ultrasound elastography combined with contrast-enhanced ultrasound has good diagnostic value in the differential diagnosis of early breast cancer.