丹红注射液对急性心肌梗死PCI围手术期心功能和TIMI血流影响的Meta分析

Meta-Analysis for Effect of Danhong Injection on Cardiac Function and TIMI During Perioperative PCI in Acute Myocardial Infarction

目的:系统评价丹红注射液对急性心肌梗死(AMI)经皮冠状动脉介入治疗(PCI)围手术期心功能和心肌梗塞溶栓治疗(TIMI)血流分级的影响。方法:计算机检索CNKI,万方数据库,维普数据库,Pub Med,CBM,Web of Science,The Cochrane Library共7个数据库,全面采集在PCI围手术期应用丹红注射液治疗急性心梗的临床试验,采用Cochrane风险评价表进行文献质量评价,运用Revman 5.3软件进行Meta分析。结果:共纳入12个临床试验,包含1131例患者,其中丹红治疗组569例,对照组562例,结果显示在常规治疗的基础上加入丹红注射液治疗,患者的左室射血分数明显增高[均数差(MD)=6.62,95%可信区间(CI)(4.91,8.34),P<0.00001],TIMI分级3级患者明显增多[相对危险度(RR)=0.22,95%CI(0.12,0.41),P<0.00001],脑利钠肽水平明显降低[MD=-151.86,95%CI(-247.00,-56.72),P=0.002]。结论:丹红注射液可以提高急性心梗PCI围手术期心功能和增加TIMI血流的分级。

Objective:Evaluate the effects of Danhong injection for perioperative percutaneous coronary intervention(PCI)on cardiac function and thrombolysis in myocardial infarction(TIMI)in patients with acute myocardial infarction(AMI).Method:Computer retrieving CNKI,Wanfang database,VIP database,PubMed,CBM,Web of Science,The Cochrane Library,gathering Danhong injection in percutaneous coronary intervention perioperative application in the treatment of acute myocardial infarction clinic trials.The Cochrane risk evaluation is adopted to improve the quality of literature evaluation,with Revman 5.3 software for Meta-analysis.Result:Participants included in 12 clinic trials contains a total of 1131 patients,including 569 patients in Danhong treatment and 562 patients in control group.The results showed that compared with conventional treatment,Danhong injection treated patients had LVEF increased obviously[mean difference(MD)=6.62,95%confidence interval(CI)(4.91,8.34),P<0.00001],the number of TIMI class 3 patients significantly increased[relative risk(RR)=0.22,95%CI(0.12,0.41),P<0.00001],and BNP levels significantly decreased[MD=151.86,95%CI(-247.00,-56.72),P=0.002].Conclusion:Danhong injection can improve the function of acute myocardial infarction after percutaneous coronary intervention.