中国肝移植术后新发消化系统恶性肿瘤文献分析报告

Literature analysis report of de novo malignant tumors of digestive system after liver transplantation in China

目的探讨我国肝移植(LT)术后新发消化系统恶性肿瘤的情况。方法检索万方数据、中国知网及维普资讯三大中文数据库中的相关文献。检索时间从各数据库建库至2019年5月9日。中文检索词为“肝移植+术后/新发+恶性肿瘤/癌”。分析我国LT术后新发消化系统恶性肿瘤受者的年龄分布、性别构成、新发肿瘤的诊断时间和累及器官、治疗及预后。结果经过筛选最终纳入文献16篇,LT后新发消化系统恶性肿瘤47例,男性受者居多;年龄51(23~65)岁,以中年(45~59岁)最多;术后新发消化系统恶性肿瘤的平均确诊时间为43(2~156)个月,以术后1~3年内发生的例数最多;结肠和胃是最为常见的肿瘤发生部位;治疗主要以手术联合放射治疗和化学药物治疗居多,但LT术后新发消化系统恶性肿瘤总体预后不佳,病死率高达51%。结论我国LT术后新发消化系统恶性肿瘤以结肠癌和胃癌为主,新发肿瘤的患者总体预后不佳,应重视术后的监测和预防。

Objective To investigate the incidence of de novo malignant tumors of the digestive system after liver transplantation(LT)in China.Methods Relevant literature review was performed from Wanfang data,China National Knowledge Infrastructure(CNKI)and Chongqing VIP.The retrieval time started from the establishment of each database to May 9,2019.The Chinese search terms were liver transplantation+postoperative/de novo+malignant tumor/cancer.The age distribution,sex composition,time of diagnosis,involved organs,treatment and clinical prognosis of recipients with de novo malignant tumors of the digestive system after LT in China were retrospectively analyzed.Results After literature screening,16 articles were eventually selected including 47 cases of de novo malignant tumors of the digestive system after LT.A majority of them were male recipients.The age of the recipients was 51(23-65)years old,most of them were middle age(45-59 years old).The average time of diagnosis of de novo malignant tumors of the digestive system after operation was 43(2-156)months,with the highest number of cases within postoperative 1-3 years.Colon and stomach were the most common tumor sites.Surgery combined with radiotherapy and chemotherapy remained the main treatment option.However,the overall clinical prognosis of patients with de novo malignant tumors of the digestive system after LT was poor with a mortality rate of 51%.Conclusions In China,colon cancer and gastric cancer are the main de novo malignant tumors of the digestive system after LT.The overall clinical prognosis of patients with de novo malignant tumors of the digestive system is poor.Sufficient attention should be paid to postoperative monitoring and prevention.