纳米颗粒联合声动力疗法的研究进展

Research progress of nanoparticles combined with sonodynamic therapy

声动力疗法(sonodynamic therapy,SDT)是一种有前景的新兴治疗方法,与手术、放疗、化疗等传统治疗肿瘤的方式相比,声动力治疗具有微创性、实时性、安全性等优势。超声波能深入到组织中并且聚焦到肿瘤区域激活超声敏化剂,提供了定点非侵入性治疗肿瘤的可能性。纳米颗粒对声动力疗法具有靶向递送、联合治疗、增强显影等优点,为提高SDT的疗效起到了极大的推动作用。本文就纳米颗粒联合声动力疗法目前的研究现状进行综述。

Sonodynamic therapy(SDT)is a new promising treatment method.Compared with traditional methods of tumors treatment such as surgery,radiotherapy and chemotherapy,acoustodynamic therapy has advan⁃tages of minimally invasive,real⁃time and safety.Ultrasound can penetrate deep into the tissue and focus on tumor area to activate the ultrasound sensitizer,providing the possibility of site⁃specific and non⁃invasive treatment of tumor.Nanoparticles have advantages of synergistic,targeted delivery,combination therapy,and enhanced visual⁃ization,etc.,which can greatly promote the efficacy of SDT.This paper reviews the current research status of nanoparticle combined with acoustic therapy.