独活寄生加减方治疗膝骨关节炎的临床疗效评价

Evaluation of Clinical Effectiveness of Duhuo Jisheng Jiajian Decoction in the Treatment of Knee Osteoarthritis

目的客观评价笔者医院有效经验方独活寄生加减方治疗膝骨关节炎-肝肾亏虚证的临床疗效。方法纳入2018年3月~2019年3月笔者医院门诊诊断为膝骨关节炎-肝肾亏虚证患者,采用随机数字表法1∶1平均分配至治疗组和对照组。治疗组予加味独活寄生加减方口服,对照组采用独活寄生汤原方《备急千金要方》,同时进行生活方式干预,连续治疗4周。采用VAS、中医证候评分进行评价。结果两组治疗前VAS和中医证候评分比较差异无统计学意义;治疗2周、4周后治疗组VAS和中医证候评分均低于对照组,差异有统计学意义(P<0.01);治疗组和对照组有效率分别为87.10%、75.86%。结论笔者医院经验方独活寄生加减方在止痹痛、改善膝关节功能方面优于独活寄生汤原方。

Objective To objectively evaluate the clinical efficacy of our hospital′s effective experience in the treatment of knee osteoarthritisliver kidney deficiency syndrome.Methods From March 2018 to March 2019,patients with a diagnosis of knee osteoarthritisliver kidney deficiency syndrome were enrolled in the outpatient depart ment of our hospital.They were randomly assigned to the treatment group and the control group by random number table method 1∶1.The treatment group was treated with Duhuo Jisheng Jiajian Decoction,while the control group was treated with Duhuo Jisheng Tang that come from the Valuable Prescriptions for Emergency.All patients received treatment of life style intervention,surrounded 4 weeks.The VAS score and the TCM syndrome score were used for evaluation.Results There was no significant difference in the scores of VAS and TCM syndromes between the two groups before treatment.The scores of VAS and TCM syndromes in the treatment group were lower than those in the control group after 2 and 4 weeks of treatment(P<0.01).The effective rates of the treatment group was 87.10%,and that of the control group was 75.86%.Conclusion The Duhuo Jisheng Jianjian Decoction is more effective than Duhuo Jisheng Tang in the treatment of acesodyne and improvement of knee joint function.