中药“补气通络汤”联合氢氯吡格雷用于非心原性短暂性脑缺血发作二级预防的临床研究

Clinical study on the secondary prevention of non-cardiogenic transient ischemic attack by using traditional Chinese medicine "Buqi Tongluo decoction" and hydroclopidogrel

目的:观察上海市浦东新区浦南医院经验方"补气通络汤"联合氢氯吡格雷用于短暂性脑缺血发作(transient ischemic attack, TIA)的临床效果及安全性。方法:将100例新发非心原性TIA患者随机分为两组,中药联合氢氯吡格雷组(中西组)及标准治疗组(西药组)各50例,西药组使用二级预防标准治疗方案,中西组使用中药及氢氯吡格雷治疗,45 d为1个治疗周期,共观察2个周期。比较两组同型半胱氨酸及血黏度水平,TIA复发及脑卒中发病情况及安全性指标。结果:两组治疗后同型半胱氨酸均下降,中西组组内、组间比较差异有统计学意义;血黏度均有下降,两组比较差异无统计学意义,TIA复发及脑卒中发病情况两组差异无统计学意义,西药组因药物不良反应脱落2例。结论:中药联合氢氯吡格雷治疗方案与推荐的标准治疗方案疗效相当,无药物不良反应,中药治疗更易为患者接受。

Objective:To observe the clinical effect and safety of the application of"Buqi Tongluo Decoction"combined with Hydroclopidogrel in the treatment of transient ischemic attack(TIA).Methods:One hundred patients with newly diagnosed noncardiogenic TIA were randomly divided into two groups:Chinese medicine combined with Hydroclopidogrel group(Zhongxi group)and standard treatment group(Western medicine group),50 cases each.Western medicine group used Standard Treatment plan,while the Zhongxi groups was treated with"Buqi Tongluo Decoction"and Hydroclopidogrel,for 90 days.Compared the two groups of homocysteine and blood viscosity,TIA recurrence and stroke incidence,safety indicators.Results:There were significant differences in homocysteine between the two groups.There were no statistically significant difference in the blood viscosity decreased.There was no statistical difference between TIA recurrence and stroke.Difference,the western medicine group fell off due to adverse drug reactions in 2 cases.Conclusion:The Chinese medicine combined with hydrochloropirol treatment is equivalent to the standard treatment,and there is no adverse drug reaction in the Chinese and Western groups.Chinese medicine treatment is more acceptable to patients and can be further studied.