血管内皮生长因子的神经保护作用

Neuroprotective effect of vascular endothelial growth factor

血管内皮生长因子,也称血管通透性因子,可以促进血管内皮细胞的增生和迁移,以及增加血管的通透性。此外,VEGF家族还与淋巴管生成、炎症反应、造血作用以及神经保护作用等有关。在缺血、缺氧或氧化应激等情况下,VEGF可以通过增加组织灌注、抑制细胞凋亡、刺激神经再生等方式起到神经保护作用。因此,VEGF在神经退行性疾病、脑卒中等神经系统疾病中的治疗作用逐渐引起重视。另一方面,抗VEGF疗法在眼部病理性新生血管性疾病的治疗中可能会导致相应的不良反应。就VEGF神经保护作用的机制及其在神经系统疾病和眼部疾病中的作用进行综述。

Vascular endothelial growth factor(VEGF),also known as vascular permeability factor,can promote the proliferation and migration of vascular endothelial cells,and enhance vascular permeability.In addition,VEGF family is also related to lymphatic vessel formation,inflammatory response,hematopoiesis and neuroprotective effect.Under the circumstances of ischemia,hypoxia and oxidative stress,VEGF can exert neuroprotective effect by increasing tissue perfusion,inhibiting cell apoptosis and stimulating neurogenesis.Therefore,therapeutic effect of VEGF in neurological diseases,such as neurodegenerative diseases and stroke has increasingly received considerable attention.On the other hand,anti-VEGF therapy for ocular pathologic neovascular diseases may lead to corresponding adverse effect.In this review,the mechanism of neuroprotective effect of VEGF and its roles in neurological diseases and ocular diseases were discussed.