金属纳米材料的植物生物效应及其多组学研究进展

Research trends of plant responses to metal nanomaterials and multi-omics analysis

金属纳米材料(MNMs)在农业领域中的广泛应用,已经引起国内外学者对其生态风险的关注。传统毒理学研究方法与组学技术(转录组学、代谢组学和蛋白质组学)相结合,逐渐成为当前纳米生态毒理学研究领域的主要手段。本文首先从植物生长效应、亚细胞及生理生化水平等不同层次,分别评述了MNMs植物效应的传统毒理学研究的主要发现;其次,阐述了转录组学、蛋白质组学以及代谢组学等多组学技术在MNMs植物毒理学领域中应用的最新研究进展,旨在进一步揭示MNMs植物效应潜在的分子机制;最后分析了该领域的研究现状、尚待解决的问题和未来发展方向,并提出今后的研究思路。

The application of metal nanomaterials(MNMs)is growing worldwide,raising concern as to whether they may present a potential risk to the environment.In combination with traditional environmental toxicology,omics technologies(e.g.,transcriptomics,metabolomics,and proteomics)have been used to sharpen understanding of toxic mechanisms of MNMs.In this review,we summarize the research related to the toxic effect of MNMs on plants at phenotypic,subcellular,physiological,and biochemical levels.We review recent advances in multi-omics technologies that provide new insights into the molecular mechanisms of MNMs phytotoxicity.To better understand the ecological ef fects of MNMs,we analyze the current research status and highlight the future challenges,perspectives,and strategies for multi-omics ap proaches.