瑞舒伐他汀钙联合曲美他嗪治疗慢性心力衰竭的疗效及对患者脑钠肽水平的影响

Therapeutic effect of rosuvastatin calcium combined with trimetazidine on chronic heart failure and its effect on brain natriuretic peptide level

目的 :探讨瑞舒伐他汀钙联合曲美他嗪治疗慢性心力衰竭的疗效及对患者脑钠肽水平的影响。方法 :纳入2016年1月-2019年1月江西省吉安市峡江县中医院收治的慢性心力衰竭患者60例,随机分为观察组和对照组各30例。对照组采用常规治疗,包括吸氧、维持水电解质平衡、合理安排作息,服用阿司匹林100 mg/次、1次/d,单硝酸异山梨脂缓释片30 mg/次、1次/d,酒石酸美托洛尔25 mg/次、2次/d。观察组在对照组基础上,再增加服用瑞舒伐他汀钙10 mg/次,1次/d,晚上口服;曲美他嗪20 mg/次,3次/d。两组均治疗4周后,观察心功能参数、脑钠肽、超敏C-反应蛋白(hs-CRP)和6 min步行距离变化。结果 :治疗后,观察组的心功能参数和6 min步行距离均优于对照组(P <0.05),且脑钠肽、hs-CRP的水平低于对照组(P <0.05)。结论 :瑞舒伐他汀钙联合曲美他嗪治疗慢性心力衰竭,可更好地改善患者心功能参数,降低脑钠肽和hs-CRP水平,提高6 min步行距离,应用价值较高。

Objective: To investigate the effect of rosuvastatin calcium combined with trimetazidine on chronic heart failure and the level of brain natriuretic peptide. Methods: From January 2016 to January 2019, 60 patients diagnosed as chronic heart failure were enrolled in Xiajiang County Hospital of traditional Chinese medicine, Jian City, Jiangxi Province. They were randomly divided into observation group and control group with 30 cases each. The control group was treated with routine therapy, including oxygen inhalation, water and electrolyte balance maintenance, reasonable schedule of work and rest, aspirin 100 mg/time once a day, isosorbide mononitrate sustained-release tablets 30 mg/time once a day, metoprolol tartrate 25 mg/time twice a day. On the basis of the control group, the observation group were treated with rosuvastatin calcium orally at night 10 mg/time once a day, trimetazidine 20 mg/time three times a day. Two groups were both treated for a period of 4 weeks. Then the cardiac function parameters, the level of brain natriuretic peptide and high-sensitivity C-reactive protein(hs-CRP), the 6 minutes walking distance were observed before and after treatment. Results: After treatment, the heart function parameters of the observation group were better than those of the control group(P<0.05), while the levels of brain natriuretic peptide, hs-CRP and 6 minutes walking distance were improved more significantly than those of the control group(P<0.05). Conclusion: Rosuvastatin calcium combined with trimetazidine in the treatment of chronic heart failure can better improve the heart function parameters and the 6 minutes walking distance, reduce the level of brain natriuretic peptide and hs-CRP, therefore it has a high application value.