5-羟色胺及其受体在肿瘤发生发展中的作用

Effects of 5-hydroxytryptamine and receptors in tumorigenesis

5-羟色胺(5-HT)在肿瘤发生发展过程中的作用受到越来越多的关注。除肠嗜铬细胞合成5-HT外,一些肿瘤细胞、免疫细胞也能分泌5-HT,且这些细胞表面存在不同的5-HT受体,5-HT作用于不同的受体,发挥多种生物学效应。5-HT激动其相应受体如5-HT1D等,能够促进肿瘤的增殖、侵袭,还可诱导肿瘤组织的血管形成。生理状态下的5-HT能够作用于免疫细胞表面的不同受体,促进免疫细胞的增殖、分泌,而在某些病理状态下,5-HT又能诱导免疫细胞向免疫抑制方向分化,从而参与肿瘤的发生发展。

The role of 5-hydroxytryptamine(5-HT)has attracted more and more attention in the development of tumor.In addition to the synthesis of 5-HT by enterochromaffin cells,some tumor cells and immune cells can also secrete 5-HT,and there are different 5-HT receptors on the surface of these cells.5-HT plays multiple biological effects through activating different receptors.5-HT promotes the proliferation and invasion of tumor and induces the angiogenesis of tumor tissues through activating its corresponding receptors,such as 5-HT1D,and so on.Furthermore,various 5-HT receptors are expressed on the surface of immune cells.On the one hand,physiological doses of 5-HT promote the proliferation and secretion of immune cells.On the other hand,pathologic 5-HT has an effect on inducing the differentiation of immune cells in the direction of immunosuppression,thus participating in the occurrence and development of tumor.