基于文献分析多囊卵巢综合征的中医证型分布及用药规律

Analysis of Traditional Chinese Medicine Syndrome Types Distribution and Medication Rules Based on Literature Analysis of Polycystic Ovary Syndrome

目的:通过文献探析中医治疗多囊卵巢综合征(PCOS)的证型分布及临床用药规律。方法:检索2003年至2018年1月1日中国期刊全文数据库(CNKI)、万方、维普3个中文数据库中相关中医治疗PCOS的临床研究文献,建立中医治疗PCOS的整体证型及临床用药数据库,并对数据进行处理、分析。结果:①共纳入符合标准的文献252篇,方剂284首;②涉及证型共37种,其中常见证型为肾虚血瘀证、痰湿证、肾虚痰瘀证,共占43.31%;③涉及病位要素以肾为主,其次为肝、脾;涉及病性要素以血瘀、痰、湿为主;④涉及药物193味,按功效共分为16类,补虚药占41.44%,活血化瘀药占16.20%,化痰祛湿药占14.90%;⑤中医治疗PCOS药性以温、平为主,药味以甘为主,辛、苦次之。结论:PCOS病因病机复杂,以肾虚为本,血瘀、痰湿为标,治疗以补肾活血、化湿祛痰为主。

Objective:To explore the distribution of syndrome types and clinical medication rules of traditional Chinese medicine(TCM)in the treatment of polycystic ovary syndrome based on literature analysis.Methods:Related clinical research literature of polycystic ovary syndrome(PCOS)treated with TCM in three Chinese databases,China National Knowledge Internet(CNKI),Wanfang data,and VIP Journal Integrative Platform(VJIP)from January 1,2003 to January 1,2018 were searched,a databased of the overall syndrome types and clinical medication database of TCM treatment for PCOS were established,and all the data were processed and analyzed.Results:①A total of 252 research papers and 284 formulas which met the criteria were included.②There were 37 TCM syndrome types involved,including kidney deficiency and blood stasis syndrome,phlegm dampness syndrome and kidney deficiency and phlegm stasis syndrome,which accounted for 43.31%.③As for the location of the disease,kidney was the organ,followed by liver and spleen.The main pathogenic factors are blood stasis,phlegm and dampness.④There were 193 Chinese medicinals invloved,which were divided into 16 types according to their function,of which,medicinals for tonifying deficiency accounted for 41.44%,medicinals for activating blood and removing blood stasis accounted for 16.20%,and medicinals for resolving phlegm and dispelling dampness accounted for 14.90%.⑤Chinese medicinals involved in the treatment of PCOS were mainly warm and mild in nature,and mainly sweet in flavor,followed by pungent and bitter.Conclusion:The etiology and pathogenesis of PCOS is complicated,with kidney deficiency as the root,and blood stasis and phlegm dampness as the branch.The treatment of PCOS is mainly invigorating the kidney and promoting blood circulation,and eliminating dampness and dispelling phlegm.