盐酸氨溴索联合小剂量红霉素治疗小儿支气管肺炎的临床疗效

Clinical study of ambroxol hydrochloride injection combined with erythromycin in the treatment of bronchopneumonia in children

目的:研究盐酸氨溴索注射液联合小剂量红霉素对小儿支气管肺炎的治疗效果。方法:选取80例患有支气管肺炎的儿童,随机分为两组。对照组40例常规治疗基础上静脉注射盐酸氨溴索注射液15 mg,2次/d。试验组40例在对照组治疗基础上加静脉滴注红霉素(10 mg/kg/d)以及0.9%NaCl注射液100 ml,1次/d。比较试验组和对照组50%肺活量时的最大呼气流速、1秒用力呼气容积、最大呼气流速峰值,主要表现症状消失时间、住院时间及不良反应发生情况。结果:接受治疗后,试验组相较于对照组而言最大呼气流速、1秒用力呼气容积、最大呼气流速峰值,均有明显的改善,差异有统计学意义(P<0.05),试验组相较于对照组而言住院时间、咳嗽消失时间、肺部啰音消失时间、退热时间、呼吸困难消失时间均明显少于对照组,差异有统计学意义(P<0.05),试验组总有效率显著高于对照组,差异有统计学意义(P<0.05),试验组相较于对照组,不良反应发生率差异无统计学意义(P>0.05)。结论:盐酸氨溴索注射液联合小剂量红霉素疗效显著,无严重的毒副作用,值得在临床推广使用。

Objective To study the therapeutic effect of ambroxol hydrochloride combined with low-dose erythromycin on children with bronchopneumonia.Method Eighty children with bronchopneumonia were randomly divided into two groups.The control group received 40 cases of intravenous injection of ambroxol hydrochloride 15 mg twice daily.Forty patients in the experimental group were given intravenous infusion of erythromycin(10 mg/kg/day)and sodium chloride injection 100 ml,once a day.The maximum expiratory flow rate,the forced expiratory volume in 1 second,and the peak expiratory flow rate were compared between the test group and the control group at 50%of the vital capacity,mainly showing the time of disappearance of the symptoms,the length of hospital stay,and the occurrence of adverse reactions.Results After treatment,the maximum expiratory flow rate,forced expiratory volume in 1 second,and peak expiratory flow rate were significantly improved in the experimental group compared with the control group(P<0.05).In the group,the hospitalization time,cough disappearance time,lung voice disappearance time,fever time,and dyspnea disappearance time were significantly less than the control group(P<0.05).The total effective rate of the test group was significantly higher than that of the control group(P<0.05),there was no significant difference in the incidence of adverse reactions between the experimental group and the control group(P>0.05).Conclusion Ambroxol hydrochloride injection combined with low-dose erythromycin has significant curative effect and no serious side effects.It is worthy of clinical use.