期刊文献+

肿瘤患者外周血T淋巴细胞亚群的变化及临床价值分析 被引量:10

下载PDF
导出
摘要 目的分析肿瘤患者外周血T淋巴细胞亚群的变化及临床价值。方法选取治疗的肿瘤组患者60例,另选取同期健康体检人员60例作为对照组。抽取所有研究人员外周静脉血2ml,采用流式细胞仪法对T淋巴细胞进行测定;另抽取肘静脉血3ml采用免疫散射比浊法测定血清中IgG、IgA、IgM含量。结果对比各组间治疗前后外周血T淋巴细胞亚群检测结果及IgG、IgA、IgM含量。治疗后肺癌、食道癌及其他肿瘤组CD3^+、CD4^+及CD4^+/CD8^+水平均高于治疗前,CD8^+水平低于治疗前,差异有统计学意义(P<0.05);与对照组相比,肿瘤组治疗前后CD3^+、CD4^+及CD4^+/CD8^+水平均较低,CD8^+水平均较高,差异有统计学意义(P<0.05);肿瘤组IgG、IgA、IgM含量均高于对照组,差异无统计学意义(P>0.05)。结论对肿瘤患者实施外周血T淋巴细胞亚群各指标测定,有助于及时准确地掌握患者免疫功能变化,从而为临床诊治提供参考依据,更好地明确治疗方案,对评估治疗效果及预后具有重要作用,值得推广应用。
作者 叶萍
机构地区 赣州市人民医院
出处 《现代诊断与治疗》 CAS 2019年第22期4005-4007,共3页 Modern Diagnosis and Treatment
  • 相关文献

参考文献10

二级参考文献63

  • 1Liu, Gang,Ren, Hong,Sun, Xue-Jun,Shi, Jing-Sen.Distribution of natural killer cells and T-lymphocyte subsets in peripheral blood,gallbladder cancer and surrounding tissue[J].Hepatobiliary & Pancreatic Diseases International,2007,6(1):81-86. 被引量:12
  • 2张洞云,邵旭,袁彤,王月云,郑睿.联合检测外周血T淋巴细胞亚群及血清CA125在卵巢良、恶性肿瘤鉴别及卵巢癌早期诊断中的应用[J].现代诊断与治疗,2007,18(3):133-136. 被引量:7
  • 3Kalathil S,Lugade AA,Miller A,et al.Higher frequenciesof GARP+CTLA-4+Foxp3+T regulatory cells andmyeloid-derived suppressor cells in hepatocellular carcino-ma patients are associated with impaired T-Cell function-ality. Cancer Research . 2013
  • 4Galletti G,Sung M S,Vahdat L T,et al.Isolation of breast cancer and gastric cancer circulating tumor cells by use of an anti HER2-based microfluidicdevice. Lab on a Chip . 2014
  • 5Schmidt K,Zilio S,Schmollinger JC,et al.Differently immunogenic cancers in mice induce immature myeloid cells that suppress CTL in vitro but not in vivo following transfer〔J〕. Blood . 2013
  • 6Carrega P,Bonaccorsi I,Di Carlo E,et al.CD56brightperforinlow noncytotoxic human NK cells are abundant in both healthy and neoplastic solid tissues and recirculate to secondary lymphoid organs via afferent lymph〔J〕. J Immunol . 2014
  • 7Mandala WL, Ananworanich J, Apompong T, et al. Control lympho-subsets: can one country's values serve for another's? [ J]. J Allergy Clin Immunol, 2014, 134(3) : 759-761. e8.
  • 8Yang H, Wu Y, Li H, et al. Reference values of T lymphocyte subsets among health adults in Inner Mongolia Region [ J ]. Int J Clin Exp Med, 2015, 8(3): 4250-4256.
  • 9Riazi Rad F, Ajdary S, Omranipour R, et al. Comparative analysis of CD4^+ and CD8^+ T cells in tumor tissues, lymph nodes and the peripheral blood from patients with breast cancer[J]. Iran Biomed J, 2015, 19(1) : 35-44.
  • 10Chen J, Yang J, Jiang J, et al. Function and subsets of dendritic cells and natural killer cells were decreased in gastric cancer[ J]. Int J Clin Exp Pathol, 2014, 7( 11 ): 8304-8311.

共引文献170

同被引文献100

引证文献10

二级引证文献14

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部