高血压肥胖者血浆促动脉硬化指数与心血管疾病风险的相关性研究

Correlation between plasma arteriosclerosis index and cardiovascular disease risk in obese patients with hypertension

目的探讨中年肥胖者血浆促动脉硬化指数(atherogenic index of plas-ma,AIP)与心血管疾病风险的相关性。方法随机选取高血压患者120例,根据内脏脂肪面积分为肥胖组和非肥胖组;根据Framingham风险评分将患者分为高危组、中危组和低危组。比较各组AIP、年龄、腰臀脂肪比、血压、体重指数、血糖和血脂,分析高血压肥胖患者AIP与心血管疾病风险的相关性。结果高血压肥胖组AIP、腰臀脂肪比、收缩压、空腹血糖、总胆固醇、三酰甘油明显高于高血压非肥胖组,差异有统计学意义(P<0.05)。中危组和高危组腰臀脂肪比、收缩压、体重指数、AIP均明显高于低危组,高危组腰臀脂肪比、收缩压、体重指数、AIP均明显高于中危组,差异有统计学意义(P<0.05)。Spearman秩相关分析结果显示,AIP与心血管因素呈正相关(P<0.05)。结论高血压肥胖者患者均有明显的血脂紊乱和高AIP值以及10年心血管风险,AIP可作为患者心血管疾病风险的重要危险因素。

Objective To investigate the association between the atherogenic index of plasma(AIP)and cardiovascular disease risk in middle-aged obese individuals.Methods One hundred and twenty patients with hypertension were randomly selected and divided into obese group and non-obese group according to visceral fat area.Patients were divided into high-risk group,medium risk group and low risk group according to Framingham Risk Score.AIP,age,waist-hip fat ratio,blood pressure,body mass index,blood sugar and blood lipids in each group were compared,and the correlation between AIP and cardiovascular disease risk in hypertensive obese patients was analyzed.Results AIP,waist-hip fat ratio,systolic blood pressure,fasting blood glucose,total cholesterol and triglyceride were significantly higher in the obese group than in the non-obese group(P<0.05).Waist-hip fat ratio,systolic blood pressure,bady mass index and AIP in the middle risk group and the high-risk group were significantly higher than those in the low risk group,and the waist-hip fat ratio,systolic blood pressure,bady mass index and AIP in the high-risk group were significantly higher than those in the middle risk group(P<0.05).Spearman correlation analysis showed that AIP was positively correlated with cardiovascular factors(P<0.05).Conclusion All patients with hypertension and obesity have significant dyslipidemia,high AIP value and 10-year cardiovascular risk,and AIP can be an important risk factor for patients with cardiovascular disease.