JNK3过表达促进心肌缺血再灌注损伤

JNK3 overexpression promoted the progression of myocardial ischemia reperfusion injury

目的分析c-Jun氨基末端激酶3(c-Jun N-terminal kinase 3,JNK3)表达与心肌缺血再灌注损伤的关系,探讨JNK3过表达对心肌缺血再灌注损伤患者的影响。方法选取心肌缺血再灌注损伤患者75例。检测患者外周血中JNK3 mRNA的表达量,比较不同临床病理组JNK3 mRNA的高表达率。结果年龄<50岁组JNK3 mRNA高表达率高于年龄≥50岁组,再灌注性心律失常组JNK3 mRNA高表达率高于无心律失常组,心肌酶学异常升高组JNK3 mRNA高表达率高于无高异常升高组,差异均有统计学意义(P<0.05);不同性别间JNK3 mRNA高表达率差异无统计学意义(P>0.05)。结论出现再灌注性心律失常及心肌酶异常升高的心肌缺血再灌注损伤患者JNK3过表达,JNK3可以作为心肌缺血再灌注损伤患者的治疗靶点。

Objective To analyze the relationship between c-Jun N-terminal kinase 3(JNK3)expression and myocardial ischemia reperfusion injury.To investigate the effect of JNK3 overexpression on the patients with myocardial ischemia reperfusion injury.Methods Seventy-five patients with myocardial ischemia reperfusion injury were selected.The expression of JNK3 mRNA in peripheral blood of patients was detected,and the high expression rate of JNK3 mRNA in different clinicopathological groups was compared.Results The high expression rate of JNK3 mRNA in the<50-year-old group was higher than that in the≥50-year-old group,the high expression rate of JNK3 mRNA in the reperfusion arrhythmia group was higher than that in the non-arrhythmia group,the high expression rate of JNK3 mRNA in the group with abnormally elevated myocardial enzyme was higher than that in the group without abnormally elevated myocardial enzyme,the difference was statistically significant(P<0.05).There was no significant difference in the high expression rate of JNK3 mRNA between different genders(P<0.05).Conclusion JNK3 was overexpressed in patients with myocardial ischemia-reperfusion injury with reperfusion arrhythmia and abnormally elevated myocardial enzymes,JNK3 can be used as a therapeutic target for patients with myocardial ischemia-reperfusion injury.