舟山海岛地区发热伴血小板减少综合征病毒流行情况及感染者IgG抗体持续时间分析

Prevalence of severe fever with thrombocytopenia syndrome virus infection in Zhoushan island and duration of serum positive IgG antibody in infected patients

目的分析舟山海岛地区人群发热伴血小板减少综合征病毒(Severe fever with thrombocytopenia syndrome virus,SFTSV)隐性感染状况及既往感染者SFTSV-IgG抗体持续时间。方法收集2019年8月浙江省舟山市健康人群1122名进行横断面研究,其中来自非流行区641名,流行区481名,采用酶联免疫吸附试验(ELISA)检测健康人群血清SFTSV-IgG抗体,并与2013年舟山市流行区和非流行区人群SFTSV-IgG抗体阳性率进行比较。同时选择2011年7月至2018年6月确诊的SFTS患者19例,采用间接ELISA法检测SFTSV-IgG抗体滴度。采用SPSS软件对数据进行分析。结果2019年流行区人群SFTSV-IgG抗体阳性率为1.5%(7/481),高于非流行区(0/641),差异具有统计学意义(χ^2=7.187,P<0.01);且SFTSV-IgG抗体阳性率均低于2013年流行区(11.7%)和非流行区(2.5%),差异亦具有统计学意义(χ^2=22.556和10.352,P<0.01)。既往确诊患者中18例血清SFTSV-IgG抗体仍为阳性,最长者可达8年。结论舟山海岛地区存在SFTSV隐性感染,SFTSV感染后患者体内SFTSV-IgG抗体可长期存在,具有一定保护力。

Objective To analyze the prevalence of severe fever with thrombocytopenia syndrome virus(SFTSV)infection in Zhoushan island of Zhejiang province and the duration of serum positive IgG antibody in patients infected with SFTSV.Methods One thousand one hundred and twenty-two healthy people from Zhoushan island of Zhejiang province were recruited for cross-sectional study in August 2019,including 641 from non-epidemic areas and 481 from epidemic areas.The serum SFTSV-IgG antibody was detected by enzyme-linked immunosorbent assay(ELISA),and the positive rates of SFTSV-IgG antibody were compared between people from the epidemic areas and non epidemic areas.Meanwhile,the antibody titer of SFTSV-IgG in 19 patients confirmed between July 2011 and June 2018 was detected by indirect ELISA.SPSS 17.0 software was used to analyze data.Results The positive rate of SFTSV-IgG antibody was 1.5%(7/481)in the epidemic area,which was higher than that in the non-epidemic area(0/641)(χ^2=7.187,P<0.01).The positive rates of SFTSV-IgG antibody in 2019 were lower than those in the epidemic area(11.7%)and non-epidemic area(2.5%)in 2013(χ^2=22.556 and 10.352,both P<0.01).The serum SFTSV-IgG antibody of 18 patients with previous infection was still positive,and the longest one lasted for 8 years.Conclusions There is a SFTSV latent infection in population from epidemic area of Zhoushan island.The SFTSV-IgG antibody can last for a long time in patients with SFTS and it may have certain protective effect.