维生素D受体多态性Taq-1和Apa-1增加多囊卵巢综合征的易感性

Vitamin D receptor polymorphisms Taq-1 and Apa-1 increase the susceptibility for developing polycystic ovary syndrome

目的探索维生素D受体(VDR)多态性与多囊卵巢综合征(PCOS)发病风险的相关性。方法利用Pubmed、Embase、Web of Science、Cochrane library和中国万方数据库,检索VDR多态性与PCOS发病风险关联性研究文献,截止日期为2018.09.30。用比值比(OR)和95%可信区间(95%CI)评估VDR多态性与PCOS发病风险的关联性强度。结果12个病例-对照研究(1824个病例和1361个健康对照)报道了4个VDR多态性(Taq-1、Apa-1、Bsm-1和Fok-1)与PCOS发病风险的关联性。9篇高质量研究的Meta分析结果显示Taq-1在隐性遗传模型下[GG比(AA+AG)]固定效应OR为1.42(95%CI=1.14~1.76),Apa-1在隐性遗传模型下[CC比(AA+AC)]固定效应OR为1.31(95%CI=1.07~1.61);Meta分析未发现Bsm-1、Fok-1多态性与PCOS发病风险的关联性。结论VDR基因多态性位点Taq-1和Apa-1以隐性遗传模型增加PCOS发生风险。

Objective To explore the association of polymorphisms in the vitamin D receptor(VDR)gene with polycystic ovary syndrome(PCOS)susceptibility.Methods Eligible studies about the association of polymorphisms in the VDR gene and PCOS susceptibility were collected by searching PubMed,Embase,Web of Science,Cochrane library and Wanfang databases.The odds ratio(OR)along with their corresponding 95%confidence interval(CI)was used to estimate the strength of associations.Results Four polymorphisms in VDR gene(Taq-1,Apa-1,Bsm-1 and Fok-1)were included in this Meta-analysis.Twelve case-control studies(1824 cases and 1361 controls)evaluated the role of four polymorphisms in PCOS risk.The Meta-analysis of nine high-quality studies on Taq-1 and Apa-1 found the fixed-effect OR reached 1.42(95%CI=1.14-1.76)and 1.31(95%CI=1.07-1.61)in the recessive genetic model,respectively.No association of Bsm-1 and Fok-1 polymorphisms with PCOS was found.Conclusion This Meta-analysis suggests that Apa-1 and Taq-1 contribute to the risk for developing PCOS under recessive genetic model.