荆花胃康胶丸与铋剂在抗幽门螺杆菌中的效果比较

Comparison of the effects of Jinghua Weikang capsules and bismuth potassium citrate in anti-Helicobacter pylori infection

目的比较荆花胃康胶丸与铋剂在抗幽门螺杆菌(Hp)治疗中的临床效果。方法采用前瞻性对照研究,选择河南大学第一附属医院2016年7月至2018年4月经胃镜尿素酶试验及13C呼气试验确诊为Hp阳性的胃十二指肠溃疡患者124例,采用随机数字表法分为A组63例、B组61例;A组采用铋剂联合"标准三联疗法"治疗,B组采用荆花胃康胶丸联合"标准三联疗法"治疗,两组疗程均为14 d。比较两组幽门螺杆菌根除率及临床疗效。结果A组、B组总有效率分别为88.9%(56/63例)、93.4%(57/61),两组差异无统计学意义(χ^2=0.795,P=0.373);A组、B组的Hp根除率分别为84.1%(53/63)、95.1%(58/61),差异有统计学意义(χ^2=3.963,P=0.047);A组、B组症状改善时间在7 d内的患者分别为68.3%(43/63)、83.6%(51/61),差异有统计学意义(χ^2=3.983,P=0.046);A组、B组不良反应的发生率分别为14.3%(9/63)、3.3%(2/61),差异有统计学意义(χ^2=4.645,P=0.031)。结论荆花胃康胶丸与铋剂相比,治疗Hp阳性胃十二指肠溃疡的临床疗效相当,但Hp根除率高,不良反应发生率低,症状改善更快。

Objective To compare the effects of Jinghua Weikang capsule and bismuth potassium citrate in the treatment of Helicobacter pylori(Hp)infection.Methods From July 2016 to April 2018,124 patients who were diagnosed as Hp positive by gastrointestinal urease test and 13C breath test at the First Affiliated Hospital of He'nan University were randomly divided into group A(63 cases)and group B(61 cases)according to the digital table.Group A received bismuth potassium citrate+standard triple therapy,treatment for 14 days.Group B was given Jinghua Weikang capsule+standard triple therapy,treatment for 14 days.One month after treatment,the treatment effect of the two regimens was recorded.Results The total effective rates of group A and group B after one course of treatment were 88.89%(56/63)and 93.44%(57/61),respectively,the difference was no statistically significant between the two groups(χ^2=0.795,P=0.373).The Hp eradication rates of group A and group B were 84.13%(53/63)and 95.08%(58/61),respectively,the difference was statistically significant(χ^2=3.963,P=0.047).The proportions of patients with improved symptoms within 7 days in group A and group B were 68.25%(43/63)and 83.61%(51/61),respectively,the difference was statistically significant(χ^2=3.983,P=0.046).The incidences of adverse reactions in group A and group B were 14.29%(9/63)and 3.28%(2/61),respectively,the difference was statistically significant(χ^2=4.645,P=0.031).Conclusion Compared with bismuth potassium citrate,Jinghua Weikang capsule has similar clinical effect after one course of treatment,higher Hp eradication rate,lower incidence of adverse reactions,faster symptom improvement,and the satisfaction and compliance of patients are higher.