抗AB对ABO血型效价及新生儿溶血病的影响

Effect of anti-AB on ABO blood group titer and neonatal hemolytic disease

目的:通过对比O型的孕妇体内IgG抗AB抗体的变化,分析抗AB效价与新生儿溶血病的关系。方法:采用2-巯基乙醇裂解IgM抗体,吸收试验结合微柱凝胶法对医院产科门诊32例孕16~28周O型、丈夫为AB型的孕妇进行IgG抗AB抗体效价检测,并对存在抗AB的各效价组、抗AB与新生儿溶血病的发生进行统计学分析。结果:32例中存在抗AB影响的有11例,其中2例效价降低了2个滴度,其余9例效价均降低了1个滴度;按照与丈夫红细胞反应的效价分组(共4组)各组间存在抗AB的差异有统计学意义(P<0.05);新生儿溶血病的发生按存在抗AB分组差异有统计学意义(P<0.01)。结论:ABO血型效价越高存在抗AB的概率越高,存在抗AB组中生育后发生新生儿溶血病的概率明显高于未存在抗AB组,建议在检测出高ABO血型效价的孕妇中检测IgG抗AB。

Objective:The relationship between anti-AB titer and neonatal hemolytic disease was analyzed by comparing the changes of IgG anti-AB antibody in pregnant women with O type.Methods:With 2-mercaptoethanol decomposition IgM antibody,absorption test combined with micro column gel method of hefei city second people's hospital of obstetrics outpatient service on May 1,2018 to 2019 on January 31,32 cases at 16 to 28 weeks pregnant women with type O her husband for AB to IgG AB antibody titer detection,and the titer of existence resistant AB group AB and the occurrence of neonatal hemolysis disease resistance for statistical analysis.Results:Of the 32 patients,11 had anti-AB effects,2 of which had a decrease in titer of 2 titers,and the remaining 9 titers were reduced by 1 titer;they were grouped according to the titer of the reaction with the husband's red blood cells.There were significant differences in anti-AB between the 4 groups(P<0.05).The incidence of hemolytic disease in neonates was statistically significant(P<0.01).Conclusion:The higher the ABO blood group titer,the higher the anti-AB probability.The probability of neonatal hemolytic disease after birth in the anti-AB group is significantly higher than that in the non-AB group.It is recommended to detect the high ABO blood group titer in pregnant women.IgG was detected in AB.