血栓通粉针剂联合西医治疗急性脑梗死患者临床观察

Clinical observation of Xueshuantong powder injection combined with western medicine on patients with acute cerebral infarction

目的急性脑梗死又称缺血性脑卒中,属于中风范畴,是神经内科常见的一种突发性疾病,具有较高的致残率及致死率,给患者生活质量造成严重负面影响。本研究探讨观察血栓通粉针剂联合西医治疗急性脑梗死患者临床疗效。方法选取2017-08-01—2018-10-31唐河县人民医院收治的急性脑梗死患者114例,遵循组间性别、年龄、发病至入院时间均衡的原则分为对照组和观察组,各57例。对照组给予常规西医治疗,在此基础上,观察组联合血栓通粉针剂治疗。观察两组疗效、血清炎症因子及神经功能缺损程度。结果对照组治疗总有效率为77.19%,低于观察组的91.23%,差异有统计学意义,P<0.05。治疗后对照组白介素-6(interleukin-6,IL-6)水平为(5.67±4.52)pg/mL,高于观察组的(4.62±2.34)pg/mL,t=6.008,P<0.001;C反应蛋白(C-reactive protein,CRP)水平为(8.64±2.47)mg/L,高于观察组的(7.42±1.87)mg/L,t=2.973,P=0.004;肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)水平为(15.34±3.47)pg/mL,高于观察组的(13.34±2.13)pg/mL,t=3.709,P=0.001。治疗后对照组美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分为(7.51±2.34)分,高于观察组的(5.61±1.20)分,差异有统计学意义,P=0.001。结论针对急性脑梗死患者给予血栓通粉针剂联合西医治疗可有效提高临床效果,降低机体炎症反应,促进患者神经功能改善。

OBJECTIVE Acute cerebral infarction,also known as ischemic stroke,belongs to the category of apoplexy.It is a common sudden disease in neurology department.It has a high disability rate and mortality rate,and has a serious negative impact on the quality of life of patients.This study observes the clinical efficacy of Xueshuantong powder injection combined with western medicine in the treatment of acute cerebral infarction.METNODS Totally 114patients with acute cerebral infarction admitted to Tanghe County People's Hospital from August 01,2017 to October 31,2018 were selected and divided into control group and observation group according to the principle of gender,age and time balance between onset and admission,57cases in each group.The control group was treated with conventional western medicine,and on this basis,the observation group was treated with Xueshuantong powder injection.The curative effect,serum inflammatory factors and degree of neurological deficit were observed.RESULTS The total effective rate of the control group was 77.19%,which was lower than that of the observation group(91.23%).The difference was statistically significant(P<0.05).The level of interleukin-6(IL-6)in the control group after treatment was(5.67±4.52)pg/ml,which was higher than that of the observation group(4.62±2.34)pg/ml,t=6.008,P<0.001;C-reactive protein(CRP)level was(8.64±2.47)mg/L,which was higher than that of the the observation group(7.42±1.87)mg/L,t=2.973,P=0.004;tumor necrosis factor-α(TNF-α)level was(15.34±3.47)pg/ml,which was higher than that of the observation group(13.34±2.13)pg/ml,t=3.709,P=0.001.After treatment,the National Institutes of Health Stroke Scale(NIHSS)score was 7.51±2.34,which was higher than that of the observation group 5.61±1.20,The difference was statistically significant,P=0.001.CONCLUSION The treatment of Xueshuantong powder injection combined with western medicine for acute cerebral infarction patients can effectively improve the clinical effect,reduce the inflammatory reaction of the body,and promote the improvement of patients'nervous function.