丁螺环酮联合帕罗西汀对改善抑郁症患者心理状态的效果研究

Effect of buspirone combined with paroxetine on mental state of depressive patients

目的探讨丁螺环酮联合帕罗西汀对抑郁症患者心理状态的改善效果。方法选择我院收治的抑郁症患者92例,按随机数表法分为两组,每组46例。对照组给予帕罗西汀治疗,观察组在此基础上给予丁螺环酮治疗。比较两组患者治疗2个月后汉米尔顿抑郁量表(HAMD)评分、汉米尔顿焦虑量表(HAMA)评分、5-羟色胺(5-HT)、血清脑源性神经营养因子(BDNF)水平及不良反应。结果治疗2个月后,两组HAMD、HAMA评分降低,5-HT、BDNF水平升高,且观察组HAMD、HAMA评分低于对照组,5-HT、BDNF水平高于对照组,P<0.05;观察组不良反应发生率与对照组比较,P>0.05。结论丁螺环酮联合帕罗西汀治疗抑郁症,可显著改善患者抑郁、焦虑的心理状态,增加5-HT、BDNF的表达,且安全性高。

Objective To explore the effect of buspirone combined with paroxetine on the improvement of psychological state of patients with depression.Methods 92 patients with depression admitted to our hospital from August 2017 to June 2018 were randomly divided into two groups,46 cases in each group.The control group was treated with paroxetine,while the observation group was treated with buspirone on the basis of the control group.Hamilton Depression Scale(HAMD)score,Hamilton Anxiety Scale(HAMA)score,serum 5-HT level,brain-derived neurotrophic factor(BDNF)level and adverse reactions were compared between the two groups after 2 months of treatment.Results After 2 months of treatment,the scores of HAMD and HAMA in the two groups decreased,the levels of 5-HT and BDNF increased;the scores of HAMD and HAMA in the observation group were lower than those in the control group and the levels of 5-HT and BDNF in the observation group were higher than those in the control group(P<0.05);the incidence of adverse reactions in the observation group was not significantly different from that in the control group(P>0.05).Conclusion Buspirone combined with paroxetine can significantly improve the psychological state of depression and anxiety,increase the expression of 5-HT and BDNF,and has high safety in the treatment of depression.