药师参与治疗对脓毒症患者细菌清除率和抗感染效果的影响

Effect of pharmacists participating in treatment on bacterial clearance rate and anti-infection effect of patients with sepsis

目的研究药师参与抗感染督导治疗对脓毒症患者细菌清除率和抗感染效果的影响。方法选取我院收治的脓毒症患者106例,采用随机数字表法分为两组,每组53例。对照组采用常规治疗,观察组在药师参与下进行治疗,比较两组病原菌清除率、治疗有效率、死亡率、住院时间、体温变化、APECHEⅡ评分及血液学相关指标。结果两组病原菌清除率、治疗有效率、住院时间及治疗过程中体温变化比较,P均<0.05;两组14天死亡率比较,P>0.05;两组白细胞计数、血清超敏C反应蛋白及降钙素原水平比较,P均<0.05。结论药师参与抗感染督导治疗可为脓毒症患者抗生素应用提供专业支持,有利于促进抗生素应用规范化、合理化,并提高脓毒症患者细菌清除率和抗感染治疗有效率,减轻机体炎症反应,促进患者康复。

Objective To explore the effect of pharmacists participating in anti-infection supervision treatment on bacterial clearance rate and anti-infection effect of patients with sepsis.Methods A total of 106 patients with sepsis were selected and randomly divided into two groups,53 cases in each group.The control group was given routine treatment and the observation group was given treatment under pharmacist participation.The pathogenic bacteria clearance rate,treatment effective rate,mortality rate,hospitalization time,temperature changes,APECHEⅡscores and hematological indicators were compared between the two groups.Results The pathogenic bacteria clearance rate,treatment effective rate,hospitalization time and temperature changes during treatment of the two groups were compared with all P<0.05;the comparison of mortality rate in 14 days between the two groups was P>0.05;the levels of white blood cell count,serum hypersensitive c-reactive protein and procalcitonin were compared between the two groups with all P<0.05.Conclusion Pharmacists participating in anti-infection supervision treatment can provide professional support for antibiotics application,which is helpful to the standardization and rationalization of antibiotics application,and increase the bacterial clearance rate and anti-infective treatment effective rate,reduce the body’s inflammatory response and promote the recovery.