炎症性肠病的自噬与表观遗传修饰

Autophagy and epigenetic modification in inflammatory bowel disease

背景:炎症性肠病是一种与肠道自身免疫相关的慢性炎症性疾病,自噬是促进免疫调节的细胞途径,相关基因的表达异常与肠道炎症以及免疫反应关系密切,而表观遗传修饰对炎症性肠病自噬的调控机制尚未阐明。目的:文章旨在对表观遗传修饰在炎症性肠病自噬中的调控作用作一介绍,以期探讨炎症性肠病自噬的发生机制。方法:检索PubMed数据库,检索时限1998年1月至2019年4月,检索关键词为“inflammatory bowel disease,autophagy,autophagy related genes,epigenetic modification,DNA methylation,histone modification,chromatin remodeling,miRNA”,选择61篇符合标准的文献。结果与结论:表观遗传(DNA甲基化、组蛋白修饰、染色质重塑、非编码RNA)可通过修饰炎症性肠病的易感基因ATG、IRGM等来调控肠道炎症、免疫以及自噬,从而介导炎症性肠病的发生和发展。

BACKGROUND:Inflammatory bowel disease is a chronic inflammatory disease associated with intestinal immune,and autophagy is a cell approach to promote immune regulation.Abnormal expression of autophagy-related genes is closely related to intestinal inflammation and immune response.However,the mechanism by which epigenetic modification regulates autophagy in inflammatory bowel disease has not been fully clarified.OBJECTIVE:To introduce the role of epigenetic modification in autophagy,and to promote a further understanding of inflammatory bowel disease.METHODS:A computer-based online research of PubMed database was performed with the key words of“inflammatory bowel disease,autophagy,autophagy-related genes,epigenetic modification,DNA methylation,histone modification,chromatin remodeling,miRNA.”The search time was from January 1998 to April 2019.Finally,61 eligible articles were included in result analysis.RESULTS AND CONCLUSION:Epigenetic modifications such as DNA methylation,histone modification,chromatin remodeling,non-coding RNA can regulate intestinal inflammation,immune and autophagy through susceptibility genes AGL and IRGM,thereby mediating the occurrence and development of inflammatory bowel disease.