液体活检在肺癌早期诊断中的应用

Research progress of liquid biopsy in early diagnosis of lung cancer

液体活检是一类新兴的病理检测技术,在肺癌的诊治方面已显示出一定的价值.对肺癌患者体液中的循环肿瘤细胞、循环肿瘤DNA、DNA甲基化、微小RNA、外泌体及肿瘤血小板进行检测可以用于肺癌的早期诊断以及预测进展.尽管目前液体活检的应用仍存在缺陷,但随着检测技术的不断发展,其可能在不远的将来成为CT等影像学检查有效的辅助或替代方法,为肺癌的诊疗提供新的方向.

Liquid biopsy is a kind of emerging pathological detection technique,which has shown certain value in the diagnosis and treatment of lung cancer.Detections of circulating tumor cells,circulating tumor DNA,DNA methylation,microRNA,exosomes and tumor educated platelets in patients′body fluids can be used for the early diagnosis and predicting the progress of lung cancer.At recent,the application of liquid biopsy still has some shortcomings.However,with the continuous development of detection technology,it may become an effective auxiliary or alternative method for imaging examination such as CT in the near future,and will provide a new direction for the diagnosis and treatment of lung cancer.