非编码RNA在胃癌中的研究进展

Research progress of non-coding RNA in gastric cancer

非编码RNA是一类无蛋白质编码功能的RNA,在肿瘤发生和发展过程中发挥重要作用.研究发现长非编码RNA、环状RNA、假基因在胃癌的发生、发展过程中发挥促癌和抑癌作用,并且可通过内源竞争RNA机制参与调控胃癌细胞增殖、凋亡、侵袭和转移等各类恶性生物学行为.另外研究还发现小干扰RNA、与Piwi蛋白相作用的RNA也可能与胃癌的发生发展有关.

Non-coding RNA is a kind of RNA,without protein coding function,which plays an important role in the occurrence and development of tumors.Studies show that long non-coding RNA,circRNA and pseudogenes play tumor-promoting and anti-tumor effects in the occurrence and development of gastric cancer,which can regulate all kinds of malignant biological behaviors of gastric cancer such as cell proliferation,apoptosis,invasion and metastasis through internal competitive RNA(ceRNA)mechanism.In addition,studies show that small interfering RNA and Piwi-interacting RNA may also be related to the occurrence and development of gastric cancer.