血浆皮质醇水平与老年抑郁症状的关系——基于如皋衰老队列

Association between plasma cortisol level and elderly depressive symptoms:based on the Rugao longevity and ageing study

目的探究血浆皮质醇水平与老年群体抑郁症状的关系。方法采用如皋衰老队列(RuLAS)2017年的调查数据,共纳入1744例70-89岁老年人,采用老年抑郁症状量表(GDS-15)对被试者的抑郁症状进行评分(35分为抑郁),晨间采血用以测量被试者的血糖和血浆皮质醇水平,采用面对面的方式完成多维度的健康评估调查问卷,并由受训练医师完成体格检查。结果如皋老年人群抑郁症状的患病率为16.5%(288/1744);肥胖人群中(BMI>28.0 kg/m^2),抑郁老人的皮质醇水平[(13.60±3.99)μmol/dl]显著高于非抑郁组[(11.51±4.06)μmol/dl],差异有统计学意义(t=2.939,P<0.01);在肥胖组中,调整了人口统计学、健康行为方式等后,血浆皮质醇水平的升高与老年抑郁症状风险的增加相关(OR=1.22,95%CI=1.08~1.37,P<0.05)。结论在如皋的肥胖老年人群中,血浆皮质醇水平的升高与抑郁症状出现的风险相关。

Objective To explore the relationship between plasma cortisol level and elderly depressive symptoms.Methods Data was collected from the Rugao Longevity and Ageing Study(RuLAS)in 2017,including 1744 older Chinese(aged from 70 to 89).The Geriatric Depression Scale(GDS-15)was used to examine the depressive symptoms in participants(M 5 points as depressive);morning blood collection was used to measure the glucose and plasma cortisol level;face to face multidimensional health assessment questionnaire was also administrated.Physical exams were performed by trained physicians.Results The prevalence of depression symptoms in Rugao elderly population was 165%(288/1744);in obese elderly people(BMI>28.0 kg/m^2),the cortisol level[(13.60±3.99)μmol/dl]of the depressed elderly was significantly higher than that of the non-depressed group[(11.51±4.06)μmol/dl],and the difference was statistically significant(t=2.939,P<0.01);In the obese group,after adjusting demographics,healthy behaviors and other factors,the increase in plasma cortisol levels was associated with an increased risk of depressive symptoms in the elderly(OR=1.22,95%CI=1.08-1.37,P<0.05).Conclusions In obese elderly people in Rugao,elevated plasma cortisol levels are associated with the risk of depressive symptoms.