国际文摘

Current Literatures

靶向FAT1抑制口腔鳞状细胞癌中LRP5/WNT2/GSS信号轴的表达,从而抑制癌变,诱导氧化应激并增强顺铂敏感性Hsu TN,Huang CM,Huang CS,et al.Targeting FAT1 inhibits carcinogenesis,induces oxidative stress and enhances cisplatin sensitivity through deregulation of LRP5/WNT2/GSS signaling axis in oral squamous cell carcinoma.Cancers(Basel),2019 Nov 27.FAT非典型钙黏蛋白1(FAT1)调节细胞-细胞黏附和细胞外基质结构,同时充当浓度依赖性肿瘤抑制因子或癌基因。尽管FAT1涉及多种恶性肿瘤,但其在口腔鳞状细胞癌(OSCC)中的作用仍不清楚。