深度水解蛋白配方奶在不同体重早产儿喂养中的临床效果观察

Clinical Application of Deep Hydrolyzed Protein Formula Milk of the Premature Infants with Different Body Weights

目的:评估深度水解配方奶(eHPF)在不同体重早产儿早期喂养中临床应用效果。方法:选取2017年9月至2018年12月出生的早产儿,分为极低出生体重儿组(体重1000-1500g之间)62例和低出生体重儿(体重1500-2000g之间)100例,每组再随机分为两组,分别予以深度水解蛋白奶(eHPF)和早产儿配方奶(SPF)喂养。极低出生体重儿组于12小时后开始微量喂养,低出生体重儿12小时内适量喂养;极低出生体重儿组深度水解蛋白奶喂养2周后改早产儿奶喂养,低出生体重儿组深度水解蛋白奶1周后改早产儿奶喂养。比较深度水解蛋白奶在不同体重早产儿早期喂养中的临床应用效果,不同体重早产儿恢复出生体重时间、每日体重增长速度、胃管留置时间、完全肠内喂养天数、住院天数、喂养不耐受发生率、宫外发育迟缓发生率及尿素氮、碱性磷酸酶指标。结果:深度水解蛋白喂养组极低出生体重儿/低出生体重儿恢复出生体重天数、完全肠道喂养天数、胃管留置时间、住院天数较早产儿奶喂养组明显缩短(P<0.05),每天体重增长优于早产儿组,喂养不耐受、宫外发育迟缓发生率明显低于早产儿组(P<0.05),尿素氮、碱性磷酸酶无统计学差异(P>0.05)。结论:深度水解蛋白奶用于不同体重早产儿早期喂养效果明显优于早产儿配方奶,其更有助于早产儿的生长发育。

Objective: To evaluate the clinical effect of extensively hydrolyzed formula(eHPF) on the early feeding of different weight premature infants. Methods: Premature infants treated in our hospital’s neonatal ward from September 2017 to December 2018 were studied, including 62 very low birth weight(weight between 1000-1500 g) and 100 low birth weight(weight between 1500-2000 g).They were randomly divided into two groups: extensively hydrolyzed formula group(observed group) and preterm formula(control group), and concretely very low birth weight were started feeding after 12 hours and changed to preterm formula after 2 weeks and very low birth weight were feeding 12 hours and changed to preterm formula after 1 weeks. The clinical effect were compared between different weight premature infants early feeding. The recovery time to birth weight, weight growth, retention time to stomach tube, time to reach full enteral nutrition, hospitalization days, feeding tolerance, the incidence of extrauterine growth retardation(EUGR) and ureanitrogon,alkaline phosphatase were observed and compared between two groups. Results: Compared with the control group, the recovery time to birth weight, full enteral feeding, retention time to stomach tube and hospitalization day of treatment group were markedly shorter,(P<0.05). The weight growth of observed group was superior to that of the preterm formula group, the feeding tolerance and the incidence of extrauterine growth retardation(EUGR) were lower than control group(P<0.05). There was no difference in the ureanitrogon, alkaline phosphatase between two groups(P>0.05). Conclusion: Extensively hydrolyzed formula is obviously better than that of preterm formula in the early feeding of premature infants with different body weights, which is more conducive to the growth and development of premature infants.