摘要
肺癌发病率及死亡率居首位,小细胞肺癌(SCLC)约占肺癌病例的15%。近年来研究发现长非编码RNA(lncRNA)(TUG1、CCAT2、PVT1、HOTTIP和HOTAIR)在SCLC的发生发展中具有一定的作用,lncRNA可在转录中、转录后和表观遗传学水平上调控相关基因水平的表达,从而影响SCLC的增殖、侵袭、转移及化疗耐药。
The incidence and mortality of lung cancer rank first,and small cell lung cancer(SCLC)accounts for about 15%of lung cancer cases.In recent years,it has been found that long non-coding RNA(lncRNA)(TUG1,CCAT2,PVT1,HOTTIP and HOTAIR)plays a significant role in the development of SCLC.lncRNA can regulate the expression of related genes at the transcriptional,posttranscriptional and epigenetic levels,and it can infulence proliferation,invasion,metastasis and chemotherapy resistance of SCLC.
作者
明超
何锐
孙远
田翎含
赵光强
Ming Chao;He Rui;Sun Yuan;Tian Linghan;Zhao Guangqiang(First Department of Thoracic Surgery,Third Affiliated Hospital of Kunming Medical University,Yunnan Cancer Hospital,Kunming 650100,China;Cancer Research Institute,Third Affiliated Hospital of Kunming Medical University,Yunnan Cancer Hospital,Kunming 650100,China)
出处
《国际肿瘤学杂志》
CAS
2019年第10期620-623,共4页
Journal of International Oncology
基金
国家自然科学基金(81702274)
云南省卫生科技计划(2018NS0071)
云南省卫生和计划生育委员会医学学科带头人培养计划(D-2017012)
云南省科技计划(2017FE467(-074))。
