摘要
立体定向体部放疗(SBRT)可通过缺氧诱导因子-1α及酸性鞘磷脂酶等生物因子有效杀伤肾癌细胞。较高生物剂量及单次照射的SBRT方案能够使晚期肾癌原发灶及转移灶得到更有效的局部控制,并且不良反应可耐受。SBRT与靶向药物联合治疗可增强肾癌对放疗的敏感性,SBRT与免疫药物联合治疗可通过远隔效应增强免疫反应。SBRT在晚期肾癌治疗相关的疗效,仍需进一步探索。
Stereotactic body radiation therapy(SBRT)can effectively kill renal cancer cells by biological molecules such as hypoxia-inducible factor-1αand acid sphingomyelinase.SBRT regimen with higher biological dose and single irradiation can achieve more effective local control of primary and metastatic lesion of advanced renal cancer,and adverse reactions can be tolerated.Combination of SBRT and targeted drugs can increase the sensitivity of renal cancer to radiotherapy,and the combination of SBRT and immune drugs can enhance the immune response through the abscopal effect.The efficacy of SBRT in the treatment of advanced renal cancer remains to be explored.
作者
蔡梁
沈亚丽
Cai Liang;Shen Yali(Lung Cancer Center,West China Hospital,Sichuan University,Chengdu 610041,China;Department of Abdominal Oncology,West China Hospital,Sichuan University,Chengdu 610041,China)
出处
《国际肿瘤学杂志》
CAS
2019年第10期627-630,共4页
Journal of International Oncology
基金
四川省科技计划(2019YJ0142)。
关键词
肾肿瘤
肿瘤晚期
立体定向体部放疗
Kidney neoplasms
Advanced tumor
Stereotactic body radiation therapy
