托莫西汀对注意缺陷与多动障碍合并焦虑患儿的效果

Effect of atomoxetine on children with attention deficit hyperactivity disorder and anxiety

目的探讨托莫西汀治疗注意缺陷多动障碍(ADHD)合并焦虑患儿的效果。方法随机数字表法将97例注意缺陷多动障碍合并焦虑患儿分为2组,常规组48例口服哌甲酯进行治疗,观察组49例予托莫西汀口服治疗,对比两组治疗1月末焦虑及ADHD症状评分、相关神经因子水平和安全性。结果观察组治疗1月末患儿ADHD症状评定分量表及总量表评分、SCARED量表中学校恐怖症、分离性焦虑、广泛性焦虑、躯体惊恐症及社交恐怖症各项评分及不良反应发生率均低于常规组,NE、DA及皮质醇水平均高于常规组(P<0.05)。结论托莫西汀可改善ADHD合并焦虑患儿NE、DA水平,缓解其ADHD及焦虑相关症状。

Objective To investigate the effect of Tomoxetine in children with attention deficit hyperactivity disorder(ADHD)and anxiety.Methods A total of 97 children with ADHD and anxiety were divided into two groups by random number table method,48 patients in the conventional group were treated with oral methylphenidate.49 patients in the observation group were treated with oral tomoxetine.Anxiety and ADHD symptom scores,associated neurotrophic levels and safety were compared between two group.Results The scores of the ADHD symptoms scale,the SCARED school phobia,the separation anxiety,the generalized anxiety,the somatic panic disorder and the social phobia in the observation group were lower than those in the conventional group,while the levels of NE,DA and cortisol were higher than those in the conventional group(P<0.05).Conclusion Tomoxetine can improve the levels of NE and DA in children with ADHD and anxiety,and relieve the symptoms of ADHD and anxiety,which is safe and effective.